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Memantine hydrochloride orally disintegrating tablet and its preparing method

The technology of oral disintegrating tablet and memantine hydrochloride is applied in the field of new drug memantine hydrochloride and improved preparation method, and can solve the problems such as the research work of the drug being carried out by many pharmaceutical factories, government departments, scientific research institutes and other institutions, To achieve the effect of improving antiviral effect, improving curative effect and good taste

Inactive Publication Date: 2005-12-21
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no dosage form of memantine hydrochloride on the market in the domestic market, but many pharmaceutical companies, government departments, scientific research institutes and other institutions are conducting research on this drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation:

[0039] After adding gelatin to proper amount of water to fully swell and dissolve, stir and add memantine hydrochloride, mix well, add crospovidone, mannitol, aspartame, orange flavor, add proper amount of water and stir to make a suspension, pour It is suitable for tablet molds, freeze-drying, until the material is completely dried and formed.

Embodiment 2

[0042] Preparation:

[0043]Add appropriate amount to make acrylic resin Eudrgit L30D-55 into a suspension, add memantine hydrochloride and mix well, add lactose, sucrose, microcrystalline cellulose, sodium saccharin, lemon, add appropriate amount of water and stir to make a suspension, pour it into a suitable In the tablet mold, freeze-dry until the material is completely dried and formed.

Embodiment 3

[0045] Component

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PUM

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Abstract

The present invention relates to a memantine hydrochloride oral disintegrant tablet and its preparation method. Its composition includes (by wt%) 2-20% of memantine hydrochloride as active component, 20-92% of filling agent, 5-30% of disintegrant agent and 1-30% of corrective agent.

Description

Technical field [0001] The invention relates to a new type of medicine memantine hydrochloride and an improved preparation method, in particular to a memantine hydrochloride orally disintegrating tablet for treating senile dementia and a preparation method thereof. Background technique [0002] Alzheimer's disease (Alzheimer's disease) is one of the common diseases of the elderly. It is mainly manifested as memory loss and recognition impairment, etc. It is a progressive neurological degenerative disorder. A large number of research data at home and abroad show that one out of ten elderly people has symptoms of dementia in varying degrees, which seriously affects people's health and quality of life. The United States is second only to AIDS in research costs related to dementia. According to reports, the incidence of Alzheimer’s disease in the United States accounts for about 10% of elderly people around the age of 65, and about 47% of elderly people over 85 years old. It has beco...

Claims

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Application Information

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IPC IPC(8): A61K31/13A61K9/20A61P25/28
Inventor 严轶东蔡金巧
Owner FUKANGREN BIO PHARMA
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