Adefovir dipivoxil orally disintegrating tablet and its preparing method

A technology of adefovir dipivoxil and orally disintegrating tablets, which is applied in the field of preparation of adefovir dipivoxil orally disintegrating tablets, can solve the problems of no related reports and literature on orally disintegrating tablets, and achieve rapid disintegration , easy to take, good taste effect

Inactive Publication Date: 2005-12-21
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The drug has already applied for patents in dosage forms such as soft capsules, dropping pills, dispersible tablets, and enteric-coated preparations, but there are no related reports and literature on orally disintegrating tablets.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] prescription:

[0035] Adefovir dipivoxil 2%

[0036] Crospovidone 55%

[0037] Microcrystalline Cellulose 30%

[0038] Lactose 25%

[0039] Sucrose 30%

[0040] Sodium Saccharin 1%

[0041] Eudrgit L30D 6.5%

[0042] Orange Flavor 0.5%

[0043] Preparation:

[0044] Add adefovir dipivoxil to Eudrgit L30D suspension, add appropriate amount of water, stir evenly, add crospovidone, microcrystalline cellulose, lactose, sucrose, sodium saccharin, orange essence, stir while adding, and form After the suspension is poured into suitable molds, freeze-dried, sealed and packaged.

Embodiment 2

[0046] prescription:

[0047] Adefovir dipivoxil 15%

[0048] Mannitol 10%

[0049] Pregelatinized Starch 10%

[0050] Guar Gum 5%

[0051] Gum Arabic 10%

[0052] Xylitol 30%

[0053] Microcrystalline Cellulose 19.5%

[0054] Lemon essence 0.5%

[0055] Preparation:

[0056] Add adefovir dipivoxil to the mixture of guar gum and gum arabic, stir evenly, then add mannitol, pregelatinized starch, xylitol, microcrystalline cellulose, lemon essence, and stir while adding to form a suspension After the liquid is poured, it is poured into a suitable mold, freeze-dried, pressed and sealed, and packaged.

Embodiment 3

[0058] prescription:

[0059] Adefovir dipivoxil 10%

[0060] Gelatin 20%

[0061] Xylitol 20%

[0062] Microcrystalline Cellulose 40%

[0063] Aspartame 4.5%

[0064] Croscarmell Starch Sodium 5%

[0065] Peach Flavor 0.5%

[0066] Preparation:

[0067] Add adefovir dipivoxil into the gelatin solution, stir evenly, add xylitol, microcrystalline cellulose, aspartame, croscarmellose sodium starch, peach essence, and stir while adding to form a suspension After the liquid is poured, it is poured into a suitable mold, freeze-dried, pressed and sealed, and packaged.

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PUM

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Abstract

The present invention relates to an Adfuweizhi oral disintegrant tablet and its preparation method. Its basic prescription composition is as follows: according to actual requirement said prescription composition can be regulated and deleted, its composition includes (by wt%) 2-20% of Adfuweizhi, 10-60% of filling agent, 5-30% of disintegrant agent, 2-20% of effervescent agent, 1-15% of corrective agent, 3-20% of metarchon agent, 1-5% of adhesive agent and 0.5-5% of lubricating agent.

Description

technical field [0001] The invention relates to a convenient medicine and a preparation method thereof, in particular to a preparation method and application of adefovir dipivoxil orally disintegrating tablets for treating various hepatitis. Background technique [0002] At present, there are 370 million hepatitis B patients in the world, and the main patients are distributed in Southeast Asia, Oceania, Africa and other countries. Almost 1 million people die each year from diseases related to the disease. Among the Chinese population, there are 120 million chronic hepatitis B virus carriers, 34 million chronic hepatitis patients, and 270,000 deaths from hepatitis B-related diseases every year, including 150,000 liver cancers. The main therapeutic drugs for hepatitis B are interferon and the nucleic acid analog lamivudine. The disadvantage of interferon is that the response rate is low, and it can cause temporary exacerbation of liver disease. It is not suitable for patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/675A61K9/20A61P1/16A61P31/14
Inventor 严轶东蔡金巧
Owner FUKANGREN BIO PHARMA
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