Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators

A compound, piperidine technology, applied in the field of tetracyclic derivatives, can solve the problems of high incidence and aggravation of leg cramps, and failure to improve the cognitive function of elderly patients
CN1745085AInactive Publication Date: 2006-03-08ORTHO MCNEIL PHARM INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ORTHO MCNEIL PHARM INC
Publication Date
2006-03-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceuticalcompositions contianing them, their use in the treatment and / or prevention of disorders mediated by oneor more estrogen receptors and processes for their preparation. The compounds of the invention areuseful in the treatment and / or prevention of disorders associated with the depletion of estrogen such ashot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
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Description

Invention field

[0001] The present invention relates to new heteroatom-containing tetracyclic derivatives, pharmaceutical compositions containing these compounds, their use in the treatment of one or more estrogen receptor-mediated diseases and their preparation methods. Thus, the compounds of the present invention can be used to treat and / or prevent estrogen deficiency related diseases (including but not limited to hot flashes, vaginal dryness, osteopenia, osteoporosis, hyperlipidemia, impaired cognitive function, Degenerative encephalopathy, cardiovascular and cerebrovascular diseases); used to treat hormone-sensitive cancer and hyperplasia of tissues (including female breast, endometrial and cervix, and male prostate); used to treat and prevent endometriosis, Uterine fibroids and osteoarthritis; and can be used as contraceptives alone or in combination with progesterone or progesterone antagonists. Background of the invention

[0002] Estrogens are a group of female hormones t...

Claims

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