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Combination of the analeptic modafinil and an antidepressant for the treatment of depression

A technology of antidepressants and inhibitors, applied in the field of application, can solve problems such as side effects of patients

Inactive Publication Date: 2006-07-05
CEPHALON INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, patients sometimes suffer side effects associated with antidepressant treatment and stop antidepressant treatment

Method used

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  • Combination of the analeptic modafinil and an antidepressant for the treatment of depression
  • Combination of the analeptic modafinil and an antidepressant for the treatment of depression
  • Combination of the analeptic modafinil and an antidepressant for the treatment of depression

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Abstract

The present invention discloses compositions and methods for treating depression by administering modafinil and an antidepressant.

Description

Background of the invention 1. Modafinil Modafinil, C 15 h 15 NO 2 S, also known as 2-(benzhydrylsulfinyl)acetamide, is a synthetic acetamide derivative with wake-promoting activity, its structure has been described in French Patent 78 05510 and US Patent 4,177,290 ('290), and It has been approved by the Food and Drug Administration for the treatment of excessive daytime associated with narcolepsy. The preparation of the racemic mixture is described in the '290 patent, and the preparation of the levorotatory isomer is described in US Patent 4,927,855 (both patents are incorporated by reference). The levoisomer has been reported to be useful in the treatment of drowsiness, depression, Alzheimer's disease, and is active against symptoms of dementia and memory loss especially in the elderly. The main pharmacological activity of modafinil is to promote wakefulness. Modafinil promotes the growth of rats (Touret et al., 1995; Edgar and Seidel, 1997), felines (Lin et al., 1992...

Claims

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Application Information

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IPC IPC(8): A61K31/165A61K31/138A61K31/4525A61P25/24
Inventor 霍华德·哈斯曼罗德尼·J·休斯
Owner CEPHALON INC
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