Method for preparing large-batch high-purity ganglioside compound
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A ganglioside, large-scale technology, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of low yield, high cost, complicated treatment process, etc., and achieve low pollution and easy Effect of regeneration and low product cost
Inactive Publication Date: 2006-08-09
商宗一
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However, the biggest disadvantage of this type of process is that the pr
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[0020] One. by the following examples, can help to understand the basic content of the present invention:
[0021] (1) The present invention selects a macroporous resin with a particle size of 30-300 mesh and an average pore diameter of 60-300 Å according to the composition, structure and properties of gangliosides.
[0022] (2) The temperature of the experimental treatment process is 0-60°C, and the pH is 1.5-6.5.
[0023] (3) Add chloroform and methanol (1:1 V / V or 1:2 V / V) to the experimental materials, homogenate at high speed, adjust the solvent ratio, add water to separate the upper layer, and pass through the macroporous resin column after proper adjustment to elute.
[0024] (4) The eluate is concentrated under reduced pressure to achieve the purpose of separation and purification.
[0025] (5) Once processed by the resin column, the purity of the product is equivalent to that of imported injections
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Abstract
The invention relates to high purity gangliosides preparation method. It includes the following steps: using higher animal brain cell as raw material; adding solvent to homogenate and do de-lamination; processing gnagliosides extracting solution by once new type macroporous resin column to gain the gangliosides which purity is more than 98%. The known gangliosides compound has extensive biological activity. And its main function is to cure and improve impaired neurological disease. The invention adopts new type macroporous resin for the first time, utilize resin structure to remove harmful substance, separate effective constituent, and keep its biological activity. It is fit for industrialization production.
Description
Technical field: [0001] It is known that gangliosides have very important biological functions, and there are about 40 to 50 kinds of them. There are about 20 kinds of mammalian fresh brain tissues, and their chemical structures are basically the same. Several main components and differences Only the number of sialic acids contained in the molecule is different, and the composition and connection position of most types of sugar chains are different. [0002] Because these compounds have many types, low content, and very similar molecular composition, structure, physical and chemical properties, etc., there is still no new process for preparing high-purity gangliosides in large quantities that is simple, efficient, and large-scale. The molecular structures of the four major gangliosides are listed here, please refer to: [0003] GANGLIOSIDES-STRUCTURE [0004] [0005] G M1 : I, II, III, IV, AG D1a : I, II, III, IV, A, BG D1b : I, II, III, IV, A, C G T1b...
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