Oral composition containing spiramycin capabile of masking bitter taster

Abstract

An orally taken composition containing foromacidin with masked bitter taste contains foromacidin, high-sweetness sugar, suspending aid, and excipient proportionally.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an oral preparation of spiramycin for masking bitter taste and a preparation method thereof. Background technique [0002] Spiramycin is a macrolide antibiotic. Research and clinical studies in recent years have shown that the antibacterial effect of spiramycin in vivo is significantly stronger than that in vitro. Because the concentration of spiramycin in tissue cells is higher than that in blood, it has a longer post-antibiotic effect and promotes neutrophils against Staphylococcus aureus. The phagocytosis of bacteria and streptococcus also has a good effect on infections caused by some newly discovered pathogenic microorganisms (such as Legionella, Cryptosporidium, etc.). Compared with erythromycin, spiramycin has the advantages of not being destroyed by gastric acid, complete absorption, good tolerance, and less toxic and side effects, so it is one of the ideal ora...

AI Technical Summary

Problems solved by technology

Although capsules can block this bitter taste, clinically, some patients, especially the elderly and children, cannot swallow or are unwilling to swallow tablets or capsules

For those who have dysphagia or children, the commonly used dosage forms are granules, dry suspensions, dispersible tablets, etc. These dosage forms can be taken after mixing with water into a suspension. Making these dosage forms must make it difficult for patients to swallow

If a large amount of sucrose or other macronutrient sugars are used to modify the flavor, it will limit the use of diabetics, and it will affect the health of children, as well as the growth of microorganisms in the process of drug preservation.

Therefore, this limits the clinical use of spiramycin