Oral composition containing spiramycin capabile of masking bitter taster

A technology of spiramycin and composition, which is applied in the field of spiramycin oral preparations for masking bitter taste and its preparation, and can solve problems such as inability to swallow, spiramycin bitterness, and difficulty in swallowing by patients

Inactive Publication Date: 2006-08-30
WUXI FORTUNE PHARMA
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although capsules can block this bitter taste, clinically, some patients, especially the elderly and children, cannot swallow or are unwilling to swallow tablets or capsules
For those who have dysphagia or children, the commonly used dosage forms are granules, dry suspensions, dispersible tablets, etc. These dosage forms can be taken after mixing with water into a suspension. Making these dosage forms must make it difficult for patients to swallow
If a large amount of sucrose or other macronutrient sugars are used to modify the flavor, it will limit the use of diabetics, and it will affect the health of children, as well as the growth of microorganisms in the process of drug preservation.
Therefore, this limits the clinical use of spiramycin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Spiramycin Granules

[0051] Every pack

[0052] Spiramycin 75MIU (about 178mg)

[0053] Acesulfame 32mg

[0054] Stevia 6mg

[0055] Microcrystalline Fiber 100mg

[0056] Sucrose 1000mg

[0057] Mannitol 2000mg

[0058] Preparation method: sieve raw and auxiliary materials, mix evenly, add a small amount of water to make binder granulation, dry and sizing to obtain dry granules.

Embodiment 2

[0060] Spiramycin granules per pack

[0061] Spiramycin 75MIU (about 178mg)

[0062] Protein sugar 30mg

[0063] Stevia 12mg

[0064] Microcrystalline Fiber 100mg

[0065] Mannitol 2500mg

[0066] Preparation method is the same as embodiment 1

Embodiment 3

[0068] Spiramycin granules per pack

[0069] Spiramycin 75MIU (about 178mg)

[0070] Protein sugar 48mg

[0071] Sodium Carboxymethyl Cellulose 300mg

[0072] Mannitol 2500mg

[0073] Preparation method is the same as embodiment 1

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

An orally taken composition containing foromacidin with masked bitter taste contains foromacidin, high-sweetness sugar, suspending aid, and excipient proportionally.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an oral preparation of spiramycin for masking bitter taste and a preparation method thereof. Background technique [0002] Spiramycin is a macrolide antibiotic. Research and clinical studies in recent years have shown that the antibacterial effect of spiramycin in vivo is significantly stronger than that in vitro. Because the concentration of spiramycin in tissue cells is higher than that in blood, it has a longer post-antibiotic effect and promotes neutrophils against Staphylococcus aureus. The phagocytosis of bacteria and streptococcus also has a good effect on infections caused by some newly discovered pathogenic microorganisms (such as Legionella, Cryptosporidium, etc.). Compared with erythromycin, spiramycin has the advantages of not being destroyed by gastric acid, complete absorption, good tolerance, and less toxic and side effects, so it is one of the ideal ora...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/16A61K9/20A61P31/04
Inventor 缪苗徐建国李勇舒建明陈娅姿包务本强解民
Owner WUXI FORTUNE PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap