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Medicine composition for treating coronary heart disease and its prepn process

A composition and technology for coronary heart disease, which can be used in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., can solve problems such as drug resistance, drug resistance, side effects, etc. Effect

Active Publication Date: 2006-10-18
ZHEJIANG XINGUANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many unresolved problems in the treatment of coronary heart disease with Western medicine, such as drug tolerance, drug resistance and side effects, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0038] Experimental Example 1 The effect of the pharmaceutical composition granules on the tolerance of mice

[0039] group

[0040] group

[0041] Experimental studies have proved that the granules of the pharmaceutical composition of the present invention can obviously improve the body tolerance of the whole animal, and prolong the survival time and swimming to death time of mice under normal pressure and hypoxia.

experiment example 2

[0042] Experimental Example 2 The effect of the pharmaceutical composition granules on the immune function of mice

[0043] group

[0044] group

[0045] Experimental studies have proved that: the granules of the pharmaceutical composition of the present invention can enhance the immune function of the body, and can improve the T lymphocyte transfer function and Mφ phagocytosis of the immunocompromised mice caused by CTX.

experiment example 3

[0046] Experimental Example 3 The effect of this pharmaceutical composition granule on acute myocardial ischemia in pigs

[0047] Observation Indicator

Reaction (+ or -)

Granule high-dose group

(2.1g / kg / d)

Granules therapeutic dose group

(0.7g / kg / d)

Huangqi Shengmai Decoction Group

(0.7g / kg / day)

spontaneous activity

increase

reduce

run away

curl up

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muscle movement

Tremor

convulsions

Ataxia

paralysis

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reaction

worrying and nervous

dull

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autonomic nervous system response

vertical hair

tears

drooling

small eyes

Protruding eyes

diarrhea

Twist

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PUM

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Abstract

The present invention discloses one kind of Chinese medicine composition for treating coronary heart disease and its preparation process. The Chinese medicine composition is prepared with the Chinese medicinal materials, including astragalus root, Dangshen, ophiopogon root, schisandra and southern schisandra. The preparation process includes water extracting, filtering, centrifuging, decompression concentrating, adding dextrin, drying, adding pharmaceutically acceptable excipient and other steps to prepare granule, capsule, dripping pill, tablet, slow releasing preparation, oral liquid or injection powder. The present invention also provides the quality control method for the Chinese medicine composition preparing process and the usage of the Chinese medicine composition.

Description

Field of Invention [0001] The present invention relates to a pharmaceutical composition and its preparation method and quality control method, in particular to a pharmaceutical composition for treating coronary heart disease and its preparation method and quality control method. Background technique [0002] Coronary heart disease is one of the most dangerous diseases of modern human beings, and it is also the most important cause of death in the adult population in my country, and the incidence is increasing day by day. [0003] Coronary heart disease, the full name of coronary heart disease, is mainly due to the narrowing of the coronary arteries supplying blood to the heart due to atherosclerosis, etc. In mild cases, angina pectoris can occur, and in severe cases, myocardial infarction and even sudden death can occur. The main clinical manifestations are chest pain or chest tightness, suffocation, especially chest pain after activities or emotional agitation. [0004] C...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/16A61K9/19A61K9/20A61K9/48A61P9/10
Inventor 王岳钧
Owner ZHEJIANG XINGUANG PHARM CO LTD
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