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Amlexanox oral membrane, and its preparing method

A technology of aminolexanol and oral film, which is applied in the field of pharmaceutical preparations for treating oral diseases, and can solve the problems of difficulty in adapting to patients with oral ulcers, inconvenient use of pastes, instability of aminolexanol, etc.

Inactive Publication Date: 2010-05-12
王法平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Because the paste is inconvenient to use, it is difficult to adapt to the needs of patients with oral ulcers. Oral film is a new form of preparation in recent years, which is suitable for patients with oral ulcers. However, there is no report of making amlexanox into oral film in the prior art , because amlexanox tastes extremely bitter, sticking it in the mouth for a long time will cause discomfort. At the same time, amlexanox is unstable, so it is necessary to find a suitable stabilizer, so find suitable ingredients to make amlexanox into an oral film It is a task of the pharmacist.

Method used

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  • Amlexanox oral membrane, and its preparing method
  • Amlexanox oral membrane, and its preparing method
  • Amlexanox oral membrane, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Amlexanol 5g

[0098] Polyvinyl alcohol (04-86) 70g

[0099] Glycerin 8ml

[0100] Purified water 330ml

[0101] Make 1000 sheets

[0102] Preparation Process:

[0103] 1. Amlexanox is crushed and passed through a 120-mesh sieve, and set aside;

[0104] 2. Grind the prescribed amount of amlexanox and glycerin with an appropriate amount of purified water to form a paste;

[0105] 3. Weigh the prescribed amount of polyvinyl alcohol and add purified water to swell, and heat to dissolve;

[0106] 4. Add the paste obtained in step 2 to the solution obtained in step 3, and mix well;

[0107] 5. Seal the suspension and place it in a 60°C environment for heat preservation and defoaming;

[0108] 6. Coating film;

[0109] 7. After the film is dried, the intermediate product is tested;

[0110] 8. Cut according to the content;

[0111] 9. Full inspection, packaging, storage.

Embodiment 2

[0113] Amlexanol 3g

[0114] Polyvinyl alcohol (04-86) 70g

[0115] Glycerin 8ml

[0116] Purified water 330ml

[0117] Make 1000 sheets

[0118] Preparation Process:

[0119] 1. Amlexanox is crushed and passed through a 120-mesh sieve, and set aside;

[0120] 2. Grind the prescribed amount of amlexanox and glycerin with an appropriate amount of purified water to form a paste;

[0121] 3. Weigh the prescribed amount of polyvinyl alcohol and add purified water to swell, and heat to dissolve;

[0122] 4. Add the paste obtained in step 2 to the solution obtained in step 3, and mix well;

[0123] 5. Seal the suspension and place it in a 60°C environment for heat preservation and defoaming;

[0124] 6. Coating film;

[0125] 7. After the film is dried, the intermediate product is tested;

[0126] 8. Cut according to the content;

[0127] 9. Full inspection, packaging, storage.

Embodiment 3

[0129] Amlexanol 2g

[0130] Polyvinyl alcohol (04-86) 70g

[0131] Glycerin 8ml

[0132] Purified water 330ml

[0133] Make 1000 sheets

[0134] Preparation Process:

[0135] 1. Amlexanox is crushed and passed through a 120-mesh sieve, and set aside;

[0136] 2. Grind the prescribed amount of amlexanox and glycerin with an appropriate amount of purified water to form a paste;

[0137] 3. Weigh the prescribed amount of polyvinyl alcohol and add purified water to swell, and heat to dissolve;

[0138] 4. Add the paste obtained in step 2 to the solution obtained in step 3, and mix well;

[0139] 5. Seal the suspension and place it in a 60°C environment for heat preservation and defoaming;

[0140] 6. Coating film;

[0141] 7. After the film is dried, the intermediate product is tested;

[0142] 8. Cut according to the content;

[0143] 9. Full inspection, packaging, storage.

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Abstract

The present invention relates to an amlexanox oral membrane preparation and its preparation method. Is composition contains amlexanox, polyvinyl alcohol, glycerine and purified water. Said invention can be used for effectively curing ulcerative stomatitis.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating oral diseases, in particular to an oral film of the drug amlexanox for treating oral ulcers and a preparation method thereof. Background technique [0002] Oral ulcer is a common oral mucosal disease, also known as aphthous ulcer. The pain is very obvious during the outbreak, and it can heal without treatment. What also have shows effect repeatedly, is called recurrent oral ulceration, has caused very big impact to patient's work and life. At present, there are many kinds of medicines for the treatment of oral ulcers, including western medicine and traditional Chinese medicine. Western medicine mainly includes steroid hormones, various antibiotics, vitamins and other medicines, but due to factors such as curative effect and side effects, the selection and use of patients are affected. Traditional Chinese medicine mainly includes powders such as Bingboran Powder and Xilei Powder, but t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/436A61K9/70A61K47/00A61P1/02
Inventor 王法平
Owner 王法平
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