Doxycycline hydrochloride freeze-dried power prepn. for injection, and process for preparing same

A technology for doxycycline hydrochloride and freeze-dried preparations, which is applied in the field of preparation of doxycycline hydrochloride freeze-dried preparations and doxycycline hydrochloride freeze-dried preparations. and other problems, to achieve the effect of excellent curative effect, overcome nausea, and simple process

Active Publication Date: 2006-11-29
GUANGDONG JIANXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Doxycycline hydrochloride tablets were introduced into the antibiotic market in the 1970s. Up to now, there have been various dosage forms such as capsules, tablets, and oral liquids. However, oral preparations have serious side effects, such as nausea, vomiting, and diarrhea. Ulcers, which interfere with the widespread use of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Prescription:

[0030] 1. Content specification: 100mg (according to doxycycline)

[0031] 2. Prescription

[0032] Name of raw and auxiliary materials 1000 pieces of consumption

[0033] Doxycycline hydrochloride 115g (equivalent to doxycycline 100g)

[0034] Vitamin C 480g

[0035] Glycine 600g

[0036] Tween 80 30ml

[0037] Add water for injection to 6000ml

[0038] Made 1000 pieces

[0039] 2. Preparation method

[0040] 1. Liquid preparation:

[0041] a. Take doxycycline hydrochloride, vitamin C, glycine and Tween 80 in a sterile room according to the above prescription and place them in a sterile container, add water for injection to about 80% of the total amount, stir and make it dissolve, add Add water for injection to the full amount and stir well;

[0042] b. Add medicinal charcoal with a concentration of 0.1% (w / v), stir for about 30 minutes, and decarbonize by coarse filtration;

[0043] c. Check the pH value and content of the filtrate. After...

Embodiment 2

[0052] 1. Content specification: 50mg (based on doxycycline)

[0053] 2. Prescription

[0054] Name of raw and auxiliary materials 1000 pieces of consumption

[0055] Doxycycline hydrochloride 57.5g (equivalent to doxycycline 50g)

[0056] Vitamin C 240g

[0057] Glycine 300g

[0058] Tween 80 15ml

[0059] Add water for injection to 3000ml

[0060] Made 1000 pieces

[0061] The preparation method is the same as in Example 1.

Embodiment 3

[0063] 1. Content specification: 200mg (based on doxycycline)

[0064] 2. Prescription

[0065]Name of raw and auxiliary materials 1000 pieces of consumption

[0066] Doxycycline hydrochloride 230g (equivalent to doxycycline 200g)

[0067] Vitamin C 960g

[0068] Glycine 1200g

[0069] Tween 80 60ml

[0070] Add water for injection to 12000ml

[0071] Made 1000 pieces

[0072] The preparation method is the same as in Example 1.

[0073] The doxycycline hydrochloride for injection of the present invention is proved to be safe through pharmacological tests, stable in product quality through stability tests, and definite clinical curative effect through clinical tests.

[0074] Pharmacological test:

[0075] It is reported in the literature that doxycycline is a tetracycline drug, which is a broad-spectrum antibacterial agent and has a bactericidal effect at high concentrations. Its mechanism of action is that the drug can specifically bind to the A position of the ribos...

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PUM

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Abstract

A freeze-dried powder injection of doxycycline hydrochloride is proportionally prepared from doxycycline hydrochloride, VC and glycine through dissolving them in the water for injection, adding the water for injection, stirring, adding medicinal carbon, stirring, coarse filtering to remove carbon, fine filtering by filtering membrane, pouring in container, and freeze-drying.

Description

Technical field: [0001] The present invention relates to a kind of doxycycline hydrochloride, especially to a kind of doxycycline hydrochloride for injection, more specifically to a doxycycline hydrochloride freeze-dried preparation for injection, the present invention also relates to this hydrochloride The preparation method of doxycycline freeze-dried preparation. technical background: [0002] Doxycycline hydrochloride is a semi-synthetic tetracyclic antibiotic. On the basis of tetracycline, the drug is modified at the 6 and 7 side chain groups to form 6-methyl-4-(dimethylamino)-3,5, 10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide hydrochloride hemiethanol hemihydrate . Its antibacterial principle is to achieve antibacterial effect by blocking all links of bacterial protein synthesis and inhibiting bacterial replication. Compared with tetracycline, it has stronger antibacterial effect (doxycycline hydrochloride antibacterial acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/65A61K47/22A61K47/18A61P31/00
Inventor 黄邦信
Owner GUANGDONG JIANXIN PHARMA
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