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Prescription of silibinin-n-methylglucamine drop pills and preparation process thereof

A technology of silybin and meglumine salt, which is applied in the field of drugs for the treatment of acute and chronic hepatitis, and can solve the problem of affecting drug dissolution and bioavailability, unreasonable silymarin tablets, and slow dissolution of Yiganling tablets and other issues, to achieve the effect of improving bioavailability, facilitating absorption, and low cost

Inactive Publication Date: 2006-12-13
孙民富
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After compression molding, the dosage form itself has problems affecting the dissolution rate and bioavailability of the drug, which seriously affects the efficacy of the drug.
Some literatures have studied the dissolution rate of Yiganling tablets, and the results show that the dissolution of Yiganling tablets is slow and the dissolution rate is low, so the bioavailability is poor.
Therefore, it is unreasonable to make tablets of poorly water-soluble silymarin, and dosage form reform should be carried out

Method used

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Experimental program
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Effect test

Embodiment

[0026] Take 25g of silibinin meglumine salt, mix it with 75g of polyethylene glycol 4000 in a container, and heat until the matrix dissolves; transfer the above molten liquid to the liquid storage tank in a vacuum state of the dropping pill machine, and keep it warm at 75°C 30 minutes; Add simethicone oil into the cooling column, the outlet temperature of the condensate is 10°C; the inner diameter of the dripper is 3mm, the outer diameter is 5mm; the molten liquid is dripped into the condensate at a rate of 30 drops per minute, and collected Dropping pills are obtained by screening and drying.

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Abstract

The invention relates to a medicament for treating acute and chronic hepatitis and process for preparation, wherein the medicament is prepared from silibinin-N-methylglucamine as the main constituent, and right mxtrix through a predetermined processing combinations. Compared with the existing dosage forms, the drop pill preparation has the advantages of short technological process, low cost of production and quick-effectiveness.

Description

(1) Technical field [0001] The invention belongs to the technical field of medicines for treating acute and chronic hepatitis, in particular to a formula and a preparation process of a drop pill preparation for treating acute and chronic hepatitis. (2) Background technology [0002] Yiganling Tablets are listed in the Chinese Ministry of Health’s standard Chinese medicine preparations. They are unilateral preparations of silymarin. Because it can improve liver function and protect liver cell membranes, it has been used as a liver-protecting drug for acute and chronic hepatitis for many years. and persistent hepatitis. According to investigations, the current sales volume of the drug is relatively low, mainly because silymarin itself is an insoluble flavonoid compound, but it is made into a tablet form. The preparation process of the tablet is that the silymarin, starch and dextrin are uniformly mixed to form granules, dried and pressed into tablets. After compression moldi...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61K9/20A61P1/16A61P31/14
Inventor 孙民富
Owner 孙民富
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