Use of angiotensin II receptors I immunogenic peptide section

An angiotensin, immunogenic technology, applied in the compound of new immunological treatment of essential hypertension, in the field of antihypertensive treatment of essential hypertension, can solve the problem of not being able to reduce the blood pressure of adult SHR, and achieve effective control Blood pressure, effect of improving compliance

Active Publication Date: 2010-08-04
WUHAN HUAJIYUAN BIOTECH DEV
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zelezna B et al. (2) use AT 1 Receptor extracellular N-terminal peptide fragment (amino acid sequence is SEQ ID NO: 14-23), actively immunized spontaneously hypertensive rats (SHR), and all animals produced antibodies against the peptide after 5 months, reducing Reduced elevated blood pressure levels in juvenile SHRs but failed to reduce already elevated blood pressures in adult SHRs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of angiotensin II receptors I immunogenic peptide section
  • Use of angiotensin II receptors I immunogenic peptide section
  • Use of angiotensin II receptors I immunogenic peptide section

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The invention provides an application of an angiotensin II receptor type 1 human immunogenic peptide, the amino acid sequence of the peptide is SEQ ID NO: 181-187 and its variants; the peptide containing the peptide is physiologically acceptable The composition of the carrier, the peptide segment is coupled to the carrier protein, and the peptide segment molecule of the coupled product is matched with an appropriate adjuvant to prepare a peptide vaccine.

[0014] At the same time, it provides the use and method of the peptide for treating essential hypertension, including administering an effective dose of vaccine. Administration procedures include standard intramuscular and subcutaneous routes and procedures, and the amount of peptide administered can be selected according to the formulation and the hypertensive state to be treated.

[0015] The invention belongs to the fields of biotechnology medicine and biotherapeutics, and relates to a compound and method for novel...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

An angiotensin IIreceptorI-type immune peptide section and its use are disclosed. The peptide section is selected from the amino-acid sequence as following: SEQ ID NO:181-187, amino-acid sequence of peptide section is Ala-Phe-His-Tyr-Glu-Ser-Arg; its analog is Ala-Phe-His-Tyr-Glu-Ser-Gln. It has excellent treatment performance, antigenicity and / or immunodominance. The use is carried out by feeding medicine by injecting for 0-8weeks. It can be used to treat primary hypertension as vaccine or medicinal composition.

Description

technical field [0001] The invention relates to the application of an angiotensin II receptor type 1 human immunogenic peptide segment, belongs to the field of biotechnology medicine and biotherapeutics, and relates to a compound used for novel immunological treatment of essential hypertension. The invention particularly relates to angiotensin II receptor type 1 (AT1) immunogenic peptides and vaccines and pharmaceutical compositions prepared with the peptides, which can be used for the antihypertensive treatment of essential hypertension. Background technique [0002] Hypertension is a disease with a high incidence that seriously endangers human health, affecting 1 billion people worldwide. The Framingham Heart Study suggests that 90% of people with normal blood pressure at age 55 are likely to develop high blood pressure during their lifetime. Hypertension is an independent risk factor for cardiovascular and cerebrovascular diseases. Effective control of blood pressure can...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06A61K38/08A61K39/00A61P9/12
Inventor 廖玉华李留东朱峰周子华魏宇淼王敏魏芬陈明程翔
Owner WUHAN HUAJIYUAN BIOTECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap