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Monascus preparation and its preparing method

A technology of red yeast rice and preparations, applied in the field of medicine, which can solve the problems of inconvenient mass-produced preparations and clinical patients taking, large differences in filling volume, large amount of starch consumption, etc., and achieves easy taking and carrying, uniform filling volume, and high bioavailability high effect

Active Publication Date: 2010-05-12
CHENGDU DIAO JIU HONG PHARMACEUTICAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large amount of starch used, and the poor fluidity after granulation, the loading capacity varies greatly, which is not convenient for large-scale production preparations and clinical patients to take
At present, there is no relevant report on making full use of the raw materials of traditional Chinese medicine red yeast rice to achieve the highest drug utilization rate

Method used

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  • Monascus preparation and its preparing method
  • Monascus preparation and its preparing method
  • Monascus preparation and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Variation of Monascus mycelia extracellular and extracellular MK (lovastatin) content at different times

[0028] Seed culture: Inoculate the slant seeds cultivated at 32°C for 5-7 days in a 250ml Erlenmeyer flask containing 40ml, and culture on a shaking table at 32°C and 180rpm for 48 hours. Shake flask culture: Inoculate the cultivated seeds with 5% inoculum amount in a 500ml Erlenmeyer flask containing 80ml of fermentation medium, and culture on a shaking table at 28-32°C and 150rpm.

[0029] On days 3, 6, 9, 12, 15, and 18, the culture supernatant and mycelia were quantitatively collected. The supernatant directly inspected the MK content; after the mycelium was washed 10 times with PBS, it was weighed quantitatively, ultrasonically crushed, and the MK (lovastatin) content was detected by reverse-phase HPLC chromatography (chromatographic conditions: the chromatographic column was Shim-pack VP-ODS C (4.6 × 150mm × 5um), the mobile phase is methanol: 18mM...

Embodiment 2

[0033] Example 2 The influence of different crushing degrees of the raw material red yeast rice of the present invention on the detection amount of mycelium lovastatin

[0034] Collect the mycelia of Example 1, dry at 105 for 24, micronize with ultra-fine grinding equipment or pulverize with a traditional Chinese medicine pulverizer, and carry out different sieve classifications to the pulverized matter:

[0035] I, 1-5um dry mycelium; II, can pass 500 mesh; III, can pass 200 mesh; VI, can pass 150 mesh; V, can pass 120 mesh; VI, can pass 80 mesh; VII, can not pass 80 mesh.

[0036] The content of MK (lovastatin) was detected by reverse phase HPLC chromatography (see Example 1).

[0037] The results show that after the dried mycelium is crushed, the detection amount of the crushed matter that can pass through the 200-mesh drug sieve is 77.2% higher than that of the crushed matter that cannot pass through the 80-mesh drug sieve, and the detection amount of the broken matter th...

Embodiment 3

[0040] Example 3 Effects of different crushing degrees on the detection amount of lovastatin in red yeast rice

[0041] The raw materials of Chinese medicine red yeast rice are crushed on the traditional Chinese medicine crusher, and the broken materials are classified by different medicine sieves; A, 1-5um Chinese medicine red yeast rice; B, can pass through 500 mesh; C, can pass through 200 mesh; D, can pass through 150 mesh; E , can pass 120 mesh; F, can pass 80 mesh; G, can not pass 80 mesh.

[0042] The content of MK (lovastatin) was detected by reverse phase HPLC chromatography (see Example 1).

[0043] Table 3 The detected amount of lovastatin in red yeast rice with different crushing degrees (unit: mg / g)

[0044] batch number

[0045] batch number

[0046]It can be seen from Table 3 that the degree of crushing has a significant impact on the detection amount of lovastatin in red yeast rice, and the detection amount of lovastatin in raw materials th...

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Abstract

The invention discloses a traditional Chinese medical monascus red agent, which is characterized by the following: the unit agent contains 200-800mg micro-powder red Monascus, the grain size of traditional Chinese medicine red Monascus is 1-200um.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a preparation prepared by crushing red yeast rice as a raw material, and belongs to the field of medicine. Background technique [0002] Red yeast rice is a kind of purple-red rice yeast that is made from rice and propagated by monascus enzyme. It is used for both medicine and food. It has a history of more than one thousand years in China. As early as in ancient times, it has been widely used in food coloring, wine making, fermentation, and traditional Chinese medicine. Red yeast rice was first recorded in "Drinking Zhengyao" in the Yuan Dynasty, and its medicinal value was recorded in "Compendium of Materia Medica"-"digesting food and promoting blood circulation, invigorating the spleen and drying the stomach, and treating red and white dysentery. Brewing wine, breaking blood and promoting medicine, Eliminate miasma in mountains and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/06A61K9/16A61K9/48
Inventor 李伯刚刘忠荣及元乔王若竹陈军白红艳黄瑜
Owner CHENGDU DIAO JIU HONG PHARMACEUTICAL FACTORY
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