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Collagen short stick using for dacryosolen embolism

A technology of collagen, short rods, applied in the field of medical biomaterials

Inactive Publication Date: 2007-02-28
TIANJIN BEIYI BIOLOGICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Since the present invention uses physical cross-linking technology, it successfully solves the problem of making short rods from type I collagen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 20 grams of commercially available type I collagen, add 0.05% acetic acid solution to 1800ml, add 2% carboxylated chitosan solution 600ml after homogenization, stir evenly and form a viscous gel, put it in a vacuum box and evacuate for 5min, Put it into the syringe pump, use No. 8 injection head to inject at a uniform speed and draw wire, put the bracket into the ultraviolet cross-linking instrument and irradiate it at 254nm for 50min to obtain a Φ0.4mm collagen rod, cut it into a short rod of about 2mm after taking it out, and seal it in a package Post-irradiation sterilization is sufficient.

Embodiment 2

[0017] 15 grams of commercially available type I collagen, add 2% hydrochloric acid solution to 1000ml, add 330ml of 5% low deacetylation degree chitosan solution after homogenization, stir evenly and form a viscous gel, put it in a vacuum box to vacuum 5min, put it into the manual syringe, select the No. 60 Irradiate at 15kGy to get a Φ0.6mm collagen rod, take it out and cut it into short rods of about 2mm, seal the package and sterilize it by radiation.

Embodiment 3

[0019] 30 grams of commercially available type I collagen, add 0.5% citric acid solution to 3600ml, add 0.8% chitosan hydrochloride solution 1200ml after homogenization, stir evenly and form a viscous gel, put it in a vacuum box to vacuum After 5 minutes, put it into a Φ0.5mm mold and freeze-dry it, then put it into a blast drying oven and dry it at 120°C for 2 hours to obtain a Φ0.3mm collagen rod, cut it into short rods of about 2mm after taking it out, seal it and pack it, and sterilize it by radiation.

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PUM

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Abstract

The invention discloses a plastic short-rod of dacryagogatresia in the medical biological material domain, which is characterized by the following: releasing and treating xeroma, reducing medical reliability for patient, saving cost.

Description

technical field [0001] The invention relates to a collagen short rod which can be used for lacrimal duct embolism and a manufacturing method thereof. This product was invented due to the needs of clinical treatment of dry eye disease. The invention belongs to the technical field of medical biomaterials. Background technique [0002] Dry eye disease is one of the high clinical incidences of ophthalmology. At present, there is no good treatment method. According to the American epidemiological survey, the incidence of dry eye disease accounts for about 20% of the population. In the United States, there are about 30 million dry eye patients who need to be treated. According to different degrees of treatment, the number of cases in our country is not less than 100 million. [0003] The causes of dry eye disease are various, and the severity of the patients is also different, but the quality of life of the patients is greatly affected, and some can cause pain in the eyes and bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61F9/007
Inventor 毕宏伟谢磊汤祥忠
Owner TIANJIN BEIYI BIOLOGICAL PRODS