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Bluish dogbane extract preparing method, and its medicinal preparation and use

A pharmaceutical preparation, the technology of Apocynum apocynum, which is applied in the field of purification and separation of effective parts of herbal medicines, can solve the problems of high cost, large loss of active ingredients, and low yield of total flavonoids

Active Publication Date: 2007-03-28
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The commonly used extraction and separation process is: alcohol extraction-water precipitation-ethyl acetate extraction method to obtain total flavonoids. These methods either cause a large loss of active ingredients or destroy the components, resulting in low yield and high cost of total flavonoids

Method used

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  • Bluish dogbane extract preparing method, and its medicinal preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take the leaves of Apocynum apocynum, crush them, add 10 times the amount of 70% ethanol to reflux and extract for 2 hours, a total of 3 times, combine the extracts, let cool, filter, recover the ethanol under reduced pressure until there is no alcohol, and concentrate to an infusion solution with a relative density of 1.3. paste, add boiling water equivalent to six times the amount of the crude drug, stir to dissolve, filter, add the filtrate to the filtrate, add 7 times the amount equivalent to the crude drug, and wash the treated polyamide column of 14-30 mesh, 14×80cm with water until it is light yellow. Elute with 70% ethanol, collect the ethanol eluent, recover the ethanol under reduced pressure, dry it in vacuum at 80°C to obtain the extract, and pulverize it to obtain the total flavonoids of Apocynum apocynum.

experiment example 2

[0052] Preparation of capsules

[0053] Apocynum total flavonoid raw material 100g, medicinal starch 100g

[0054]Pass the total flavonoids of apocynum and medicinal starch through a 100-mesh sieve, mix well, and granulate with an appropriate amount of ethanol. Dry at 60°C, granulate, and pack into capsules.

experiment example 3

[0056] Tablet preparation

[0057] Apocynum total flavonoid raw material 100g, medicinal starch 100g

[0058] Pass the total flavonoids of apocynum and medicinal starch through a 100-mesh sieve, mix well, and granulate with an appropriate amount of ethanol. Dried at 60°C, granulated by a granulator, and compressed into tablets.

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PUM

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Abstract

The present invention discloses a dogbane total flavone and its contained effective component hyperin, isoquercitrin and quercetin, etc. The present inention also discloses a preparation method of dogbane total flavone. Said method includes the following steps: using Chinese medicinal material dogbane as raw material, adding ethyl alcohol to make extraction, recovering ethyl alcohol to obtain alcoholic extract, dissolving said extract in boiling water, filtering, feeding the supernatant fluid into polyamide column, using water to make elution, then using ethyl alcohol to make elution, collecting eluent, recovering ethyl alcohol, vacuum drying to obtain dried dried extract, using colorimetry to determine dogbane total flavone content, and using said dried extract as medicinal effective component. Said dogbane total flavone content is up to above 50%.

Description

technical field [0001] The invention belongs to the technical field of separation and purification of effective parts of botanical medicines, and can make the total flavonoid content of the effective parts of apocynum more than 50%, reaching the national standard of Class 5 traditional Chinese medicine raw materials. [0002] Pharmacological activity of Apocynum apocynum, literature reports have anti-cerebral ischemic effect of total apocynum flavonoids, research on anti-aging effects, effects on blood sugar and renal function of alloxan mice Background technique [0003] Commonly used extraction and separation processes are: alcohol extraction-water precipitation-ethyl acetate extraction method to obtain total flavonoids. These methods either cause a large loss of active ingredients or destroy the components, resulting in low yields of total flavonoids and high costs. Therefore, it is necessary to study a new simple and efficient extraction and separation method, which is s...

Claims

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Application Information

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IPC IPC(8): A61K36/24A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P9/10A61P39/06A61K127/00
Inventor 杨新波黄正明曹文斌陈红艳杨坤
Owner GENERAL HOSPITAL OF PLA
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