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Infantile overfood dispersing tablets

A technology for children's favorite food and dispersible tablets, applied in the direction of pill delivery, etc., can solve the problems of difficult industrialization, adhesion, high proportion and content, and achieve the effect of large room for manoeuvre and improvement of disintegration degree.

Inactive Publication Date: 2011-01-12
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most compound Chinese medicine dispersible tablets contain about 30-50% of the main drug. It is not easy to rely on the remaining drug adjuvants to ensure rapid disintegration in 3 minutes and maintain a considerable dissolution rate. Most of the drugs contain macromolecular substances such as pectin and polysaccharides, which adhere to the surface when the TCM dispersible tablet disintegrates, which has a negative impact on the disintegration and dissolution of the drug.
[0011] In summary, most of the compound Chinese medicine dispersible tablets are difficult to control the disintegration speed of Chinese medicine dispersible tablets at 3 due to (1) the high proportion of main ingredients of traditional Chinese medicine, and (2) the adhesion of macromolecular substances such as pectin and polysaccharides. The requirement within minutes is more difficult to industrialize than Western medicine dispersible tablets
There are many types of industrialized Western medicine dispersible tablets, but there are very few industrialized Chinese medicine dispersible tablets.

Method used

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  • Infantile overfood dispersing tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The raw materials of Chinese medicine for Xiaoerxishi dispersible tablets: Liushenqu (stir-fried) 77g, Citrus aurantium (stir-fried) 39g, Atractylodes macrocephala (fried) 39g, hawthorn 59g, rice sprout (stir-fried) 192g, malt (stir-fried) 192g .

[0056] The weight percentage of traditional Chinese medicine extract and auxiliary materials of Xiaoerxishi dispersible tablets: 25% fine powder of Xiaoerxishi extract, 36% sodium carboxymethyl starch, 8% low-substituted hydroxypropyl cellulose, 8% microcrystalline cellulose , Lactose 18%, polyvinylpyrrolidone 3%, magnesium stearate 2%.

[0057] Xiaoerxishi dispersible tablets are obtained according to the following specific steps: the above six flavors, malt and rice sprouts are decocted twice in water for 30 minutes each time, the decoction is combined, filtered, and the filtrate is concentrated into a thick paste; the remaining Liushenqu and other four flavors It is pulverized into a fine powder, mixed with the above thick pas...

Embodiment 2

[0060] The weight percentage of fine powder of pediatric food extract is 30.4%, sodium carboxymethyl cellulose 21.8%, microcrystalline cellulose 15.4%, cross-linked polyvinylpyrrolidone 15.4%, polyvinylpyrrolidone 6.6%, lactose 5%, polyethylene Pyrrolidone 3.3%, micronized silica gel 0.9%, and magnesium lauryl sulfate 1.2%. The rest is the same as in Example 1.

Embodiment 3

[0062] The weight percentage of the fine powder of pediatric food extract is 40.3%, sodium carboxymethyl starch 25.8%, croscarmellose sodium 11.7%, cross-linked polyvinylpyrrolidone 2.9%, low-substituted hydroxypropyl cellulose 7.5% , Mannitol 4.5%, polyvinylpyrrolidone 2.9%, micro-powder silica gel 2.2%, magnesium stearate 1%, HLB=15-16 sucrose fatty acid ester 1.2%. The sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, and the rest are the same as in Example 1.

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Abstract

A dispersing tablet preferable for baby for treating simple indigestion, anorexia and diarrhea caused by indigestion is prepared from 6 Chinese-medicinal materials including maticated leaven, bitter orange, haw, germinated barley, etc and proper auxiliary.

Description

Technical field [0001] The invention relates to the technical field of dispersible tablets of Chinese patent medicines, in particular to a dispersible tablet that children like to eat. Background technique [0002] Dispersible tablets are a new drug formulation developed in recent years. There are many formulations of children's favorite foods, which have the effects of strengthening the spleen, digesting food, and reducing accumulation. It is used to treat children's simple dyspepsia, loss of appetite and diarrhea caused by indigestion. One of the original dosage forms of Xiaoerxishi sugar-coated tablets has been listed in the Chinese Pharmacopoeia. Xiaoerxishi sugar-coated tablets have slow dissolution, poor absorption and low bioavailability. [0003] Compared with ordinary tablets, dispersible tablets require that the temperature of the disintegration medium is 20±1°C, the disintegration time limit is less than 3 minutes, and all the disintegrated particles should pass throug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20
Inventor 罗晓健王跃生吕爱平饶毅张国松饶小勇曾志斌
Owner JIANGXI HERBFINE HI TECH