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Application of curcumin in preparing medicine for inventing drug resistance of malignant tumor

A technology of malignant tumors and curcumin, which is applied in the direction of anti-tumor drugs, drug combinations, non-active ingredients of polymer compounds, etc., to achieve the effects of low price, pain relief, and wide-ranging sources

Inactive Publication Date: 2007-06-06
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But, the application of curcumin as the drug resistance reversing drug of other malignant tumors except above three kinds for the preparation treatment has not been reported yet.

Method used

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  • Application of curcumin in preparing medicine for inventing drug resistance of malignant tumor
  • Application of curcumin in preparing medicine for inventing drug resistance of malignant tumor
  • Application of curcumin in preparing medicine for inventing drug resistance of malignant tumor

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0019] Preparation Example 1: Weigh 100 mg of curcumin (purity ≥ 95%), add 40 ml of absolute ethanol to dissolve it, drop it into 60 mL of β-cyclodextrin saturated aqueous solution (85.0 g / l) at 55 ° C, and stir 1h, stop heating, continue stirring for 5h to obtain an orange-yellow suspension, leave it at room temperature for 12h, pass through an 80-mesh sieve, and dry at 50°C to obtain an orange-yellow drug powder, namely curcumin-β-cyclodextrin inclusion compound. The clathrate powder and 0.9% normal saline are dissolved in 0.9% normal saline (0.9g sodium chloride is dissolved in 100ml distilled water) by mass ratio of 3: 1, and the gained solution is filtered and sterilized to obtain the effective drug combination of curcumin thing. When used, it is properly diluted with 0.9% physiological saline according to the required concentration.

preparation Embodiment 2

[0020] Preparation Example 2: Weigh 50 mg of curcumin (purity ≥ 95%), add 5 ml of Tween-80, grind for 30 min, add 2 ml of absolute ethanol and 30 ml of 0.9% normal saline, and continue grinding for 2 hours to obtain a clarified curcumin medicinal solution , filter, and sterilize to obtain an effective pharmaceutical composition of curcumin. When used, it is properly diluted with 0.9% physiological saline according to the required concentration.

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Abstract

The present invention relates to the application of curcumin in preparing medicine for inverting drug resistance of malignant tumor. The malignant tumor includes oophoroma, cervix cancer, endometrial carcinoma, lung cancer, liver cancer, etc. The effective component of the medicine includes curcumin, demethoxy curcumin, didemethoxy curcumin or their mixture. The medicine consists of the effective component, solvent, stabilizer and co-solvent. It is used to act on drug resisting cell of malignant tumor alone or together with cisplatin or other chemotherapeutic medicine. Compared with traditional drug resistance inverting medicine preparation, the present invention has the advantages of small dosage, high safety and high efficiency.

Description

technical field [0001] The invention relates to the application of curcumin for preparing a drug-reversal drug for treating malignant tumor resistance, in particular to the application of curcumin for preparing a drug-resistant drug-reversal for treating ovarian cancer and other malignant tumors. Background technique [0002] Chemotherapy is one of the main means of treating tumors. Multidrug-resistance (MDR) produced by tumor cells has become the main obstacle affecting the curative effect of tumor chemotherapy. According to relevant statistics, more than 90% of cancer patients die from multiple or multiple causes. Most of them are related to drug resistance, so finding low-toxic and effective MDR reversal agents is an important method to improve the efficacy of chemotherapy. At present, a variety of multidrug resistance reversal agents are in the basic and clinical trials. The reasons for drug resistance of tumor cells are complex, but the drug resistance protein produced...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K47/40A61P35/00
Inventor 刘志强关松磊宋凤瑞刘忠英胡秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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