Anti-CD38 human antibodies and uses therefor.
A humanized antibody and antibody technology, applied in the direction of anti-animal/human immunoglobulin, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, drug combination, etc., can solve the problem of low affinity and efficacy, not suitable for human beings etc.
Active Publication Date: 2007-06-06
MORFOZIS AG
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However, we found in clinical trials that OKT10 has relatively low affinity and efficacy when it is a chimeric construct
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The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, hematological malignancies such as multiple myeloma. Antibodies of the invention also can be used in the diagnostics field, as well as for investigating the role of CD38 in the progression of disorders associated with malignancies. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. The invention also provides isolated novel epitopes of CD38 and methods of use therefore.
Description
This application claims U.S. Provisional Application 60 / 541,911 filed February 6, 2004, U.S. Provisional Application 60 / 547,584, filed February 26, 2004, U.S. Provisional Application 60 / 553,948, filed March 18, 2004, and 2004 Priority to U.S. Provisional Application 60 / 599,014, filed August 6, the contents of which are hereby incorporated by reference in their entirety. Background of the invention CD38 is a type II membrane glycoprotein that belongs to the family of extracellular enzymes due to its enzymatic activities of ADP ribosyl cyclase and cADP hydrolase. During ontogeny, CD38 is present on CD34+ committed stem cells as well as lineage-committed progenitors of lymphocytes, erythroid and myeloid cells. CD38 is thought to be expressed only in the lymphoid lineage during the early stages of T and B cell development. Upregulation of CD38 may serve as a marker of lymphocyte activation—particularly B cell differentiation along the plasmacytoid pathway. The (co-)receptor fu...
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Inventor 迈克尔·特萨尤特·伊格尔
Owner MORFOZIS AG
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