Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-CD38 human antibodies and uses therefor.

A humanized antibody and antibody technology, applied in the direction of anti-animal/human immunoglobulin, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, drug combination, etc., can solve the problem of low affinity and efficacy, not suitable for human beings etc.

Active Publication Date: 2007-06-06
MORFOZIS AG
View PDF3 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we found in clinical trials that OKT10 has relatively low affinity and efficacy when it is a chimeric construct containing human Fc part
In addition, OKT10 is a murine antibody and therefore not suitable for administration to humans

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-CD38 human antibodies and uses therefor.
  • Anti-CD38 human antibodies and uses therefor.
  • Anti-CD38 human antibodies and uses therefor.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, hematological malignancies such as multiple myeloma. Antibodies of the invention also can be used in the diagnostics field, as well as for investigating the role of CD38 in the progression of disorders associated with malignancies. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. The invention also provides isolated novel epitopes of CD38 and methods of use therefore.

Description

This application claims U.S. Provisional Application 60 / 541,911 filed February 6, 2004, U.S. Provisional Application 60 / 547,584, filed February 26, 2004, U.S. Provisional Application 60 / 553,948, filed March 18, 2004, and 2004 Priority to U.S. Provisional Application 60 / 599,014, filed August 6, the contents of which are hereby incorporated by reference in their entirety. Background of the invention CD38 is a type II membrane glycoprotein that belongs to the family of extracellular enzymes due to its enzymatic activities of ADP ribosyl cyclase and cADP hydrolase. During ontogeny, CD38 is present on CD34+ committed stem cells as well as lineage-committed progenitors of lymphocytes, erythroid and myeloid cells. CD38 is thought to be expressed only in the lymphoid lineage during the early stages of T and B cell development. Upregulation of CD38 may serve as a marker of lymphocyte activation—particularly B cell differentiation along the plasmacytoid pathway. The (co-)receptor fu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07K16/28A61P37/00
Inventor 迈克尔·特萨尤特·伊格尔
Owner MORFOZIS AG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com