Process for production of azulene derivatives and intermediates for the synthesis of the same

A technology of derivatives and compounds, applied in the field of production of azulene derivatives and intermediates for the synthesis of the azulene derivatives, can solve the problems of production, cost and environmental protection that are not completely satisfactory
CN1984898AInactive Publication Date: 2007-06-20ASTELLAS PHARMA INC +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ASTELLAS PHARMA INC
Publication Date
2007-06-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process for producing azulene derivatives useful as Na+-glucose cotransporter inhibitor easily and simply in high yield at a low cost which is industrially advantageous and excellent in environmental protection, characterized by subjecting at least one compound selected from among specific penta- and tetraacyl precursors of the azulene derivatives and salts of the precursors to reduction and deblocking to obtain a C-glycoside compound; and useful intermediates obtained in the above process.
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Description

technical field

[0001] The present invention relates to can be used as Na + - Process for the production of azulene derivatives of glucose cotransporter inhibitors, and intermediates for the synthesis of such azulene derivatives. More specifically, the present invention relates to a method for producing azulene derivatives, which is high in yield, simple in operation, low in cost, suitable for environmental protection and industrially advantageous, and the azulene derivatives obtained during the method can be used to synthesize such Intermediates of azulene derivatives. Background technique

[0002] It is known that azulene derivatives and salts thereof represented by the following structural formula (6) have the ability to inhibit Na + - Action of glucose co-transporter, useful as a therapeutic agent for diabetes, etc. [See, WO 04 / 13118 pamphlet (hereinafter referred to as Patent Document 1)].

[0003] [Structural formula (6)]

[0004]

[0005] In structural formula ...

Claims

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