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Blackberry lily isoflavone compound and its application in medical field

A kind of compound and isoflavone technology, applied in the fields of natural medicinal chemistry and medical technology

Inactive Publication Date: 2007-06-27
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports on the estrogen-like effect of total isoflavones and its components in Shegan and the prevention and treatment of women's menopausal syndrome

Method used

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  • Blackberry lily isoflavone compound and its application in medical field
  • Blackberry lily isoflavone compound and its application in medical field
  • Blackberry lily isoflavone compound and its application in medical field

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 The preparation method of Shegan total isoflavones

[0017]Shoot dry 10Kg of medicinal materials, heat extract three times with 10 times the amount of 95% ethanol, each extraction time is 100 minutes, filter, and recover the ethanol from the filtrate under reduced pressure, add water to dilute to 10 times the volume, and apply the treated AB-8 macroporous resin Column, first eluted 5 column bed volumes with water, then eluted 5 column bed volumes with 90% ethanol, collected the 90% ethanol part of the eluate, recovered ethanol under reduced pressure, concentrated and dried, and obtained 198 g of total isoflavones (Yield 2.5%). After testing, the content of isoflavones in the extract is 91%. The obtained total isoflavones are separated by silica gel, gel and other column chromatography to obtain the above 19 isoflavones. Their chemical structures were determined by spectroscopic analysis and comparison with the literature. Among them, the specific separat...

Embodiment 2

[0019] Example 2 Experiment of the effect of Shegan total isoflavones on the estrogen level in rats

[0020] 2.1 Purpose of the experiment: To study the effect of gavage administration of total isoflavones of Shegan on estrogen in female castrated rats, and plan to use it for the treatment of female menopausal syndrome in the future.

[0021] 2.2 Experimental materials:

[0022] 2.2.1 Shegan total isoflavones: self-made.

[0023] 2.2.2 Soybean Isoflavones: Handan Mailang Plant Extraction Co., Ltd., batch number: 20040412

[0024] 2.2.3 Penicillin sodium for injection: Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd., batch number: 05019321

[0025] 2.2.4 0.9% normal saline: Shanghai Huayuan Changfu Pharmaceutical (Group) Co., Ltd., batch number: 05112503

[0026] 2.3 Dosage: The solvent group was given normal saline, and the dry total isoflavones were divided into three dosage groups (300mg / kg, 600mg / kg and 900mg / kg), and the positive control used soybean isoflavones 1000mg...

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Abstract

The present invention relates to natural medicine chemical technology, and is especially one kind of new isoflavonoid glycoside BC-17, chemically named as 5, 3', 5'-trimethoxy-6, 7-methylene dioxy isoflavonoid -4'-O-beta-D-glucoside, extracted from Belamcanda chinensis and its application in preparing medicine and health food for preventing and treating women's lower estrogen level and climacteric syndrome.

Description

Technical field: [0001] The present invention relates to the field of natural medicinal chemistry and medical technology, and relates to the chemical structure of a new compound of Shegan isoflavones extracted and separated from the dried rhizome of Shegan Belamcanda chinensis (L.) DC. The application of the Shegan isoflavone compound including the new compound in the preparation of medicine or health food for the prevention and treatment of low estrogen level and women's climacteric syndrome. Background technique: [0002] Shegan is the dry rhizome of Belamcanda chinensis (L.) DC. First recorded in "Shen Nong's Materia Medica", it tastes bitter and cold, and enters the liver and lung meridians. It is a commonly used Chinese herbal medicine and is rich in resources. Studies have shown that Shegan is rich in isoflavones, which is one of its characteristic components. It has been reported that the main components contained in Shegan are irisgenin, irisaxanthin, subirisaxant...

Claims

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Application Information

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IPC IPC(8): C07H17/04A61K31/7048A61P15/12
Inventor 陈海生金丽刘建国金永生赵卫权
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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