Methods and compositions for treatment of asthma

Abstract

The present invention comprises methods and compositions for the treatment of bronchorestrictive disorders, including asthma, in humans or animals. The methods and compositions are effective in treatment of inflammatory responses, such as those found in asthma and other related pathologies.

Description

[0001] This application claims priority to U.S. Provisional Application No. 60 / 040,745, filed Mar. 13, 1997.[0002] The present invention relates to methods and compositions for the treatment of pathologies associated with asthma and inflammatory responses in a human or animal. In particular, the present invention comprises compositions and methods for the treatment of asthma by administration of pharmaceutical preparations including D-propranolol.[0003] More than ten million persons in the United States suffer from asthma and related inflammatory lung diseases. The numbers of persons with asthma is increasing both in the United States and worldwide. The morbidity associated with asthma makes asthma a major medical condition. Asthma is the most common chronic disease of childhood and the leading cause among chronic illnesses of school absences. Asthma in humans results in an estimated 27 million patient visits, 6 million lost workdays, and 90.5 million days of restricted activity per...

AI Technical Summary

Benefits of technology

[0014] In accordance with the present invention, compositions and methods are provided that are effective in preventing asthma and related pathologies. These methods and compositions are effective against inflammatory reactions in humans or animals. These compositions are easily administered by an oral route and can be given in dosages that are safe and effective. The present invention provides a method of treating asthma and related pathologies by administering a composition comprising a compound with anti-oxidant properties in a dosage sufficient to inhibit asthma.

[0022] Still another object of the present invention is to provide methods and compositions that are effective in diminishing specific and non-specific bronchial hyperreactivity.

[0051] The lung is protected from neutrophil elastase and other such enzymes by several antiproteinases such as .alpha..sub.1-proteinase inhibitor (.alpha..sub.1-PI) and secretory leucoprotease inhibitor (SLPI). In a noninflamed lung, the activity of these antiproteinases functions to control proteinase activity and prevents proteinase damage to the lung. During neutrophil stimulation in an inflamed lung, in addition to proteinase release, stimulated neutrophils release reactive oxygen metabolites and the oxidative enzyme, myeloperoxidase. Not only are the reactive oxygen metabolites damaging to lung tissue, the protective antiproteinases are turned off by oxidative inactivation. Thus, compounds having antioxidative activity, such as those of the present invention, could function both in lung tissue protection and in preventing the inactivation of the protective enzymes.

[0056] The compounds described above can be provided as pharmaceutically acceptable formulations using formulation methods known to those of ordinary skill in the art. These formulations can be administered by standard routes. In general, the combinations may be administered by the topical, transdermal, oral, nasal, rectal or parenteral (e.g., intravenous, subcutaneous or intramuscular) route. In addition, the combinations may be incorporated into biodegradable polymers allowing for sustained release of the compound.

[0061] A tablet may be made by compression or molding, optionally with one or more accessory ingredients. Compressed tablets may be prepared by compressing, in a suitable machine, the active ingredient in a free-flowing form such as a powder or granules, optionally mixed with a binder, lubricant, inert diluent, preservative, surface active or dispersing agent. Molded tablets may be made by molding, in a suitable machine, a mixture of the powdered compound moistened with an inert liquid diluent. The tablets may be optionally coated or scored and may be formulated so as to provide a slow or controlled release of the active ingredient therein.

Problems solved by technology

Additionally, asthma reactions are a growing problem for animals.

In particular, the horse racing industry is affected by horses that suffer from asthmatic reactions.

The histamine then attaches to receptor sites in the larger bronchi, causing irritation, inflammation and edema.

Without adequate compensation, hypoxia, and in extreme cases, respiratory acidosis may result.

The current treatments for asthma are not adequate and many have serious side effects.

Though scrupulous housecleaning and air cleansing devices can lessen the exposures to allergens, it is very difficult to eliminate all exposures to allergens.

Additionally, many of these compounds are rapidly metabolized and have very short half-lives, and thus are not effective therapy for asthma or hyperresponsiveness reactions.

The side effects of theophylline are nervousness, nausea, vomiting, anorexia, abdominal discomfort and headache.

It is difficult to reach an effective drug level that provides asthma control without triggering side effects.

These agents have tremendous toxicity in children, including adrenal suppression and reduced bone density and growth.

In all age groups, corticosteroids have numerous side effects and complications which impact major organ systems.

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