Methods and compositions for treatment of asthma

Abstract

The present invention comprises methods and compositions for the treatment of bronchorestrictive disorders, including asthma, in humans or animals. The methods and compositions are effective in treatment of inflammatory responses, such as those found in asthma and other related pathologies.

Description

[0001] This application claims priority to U.S. Provisional Application No. 60 / 040,745, filed Mar. 13, 1997.[0002] The present invention relates to methods and compositions for the treatment of pathologies associated with asthma and inflammatory responses in a human or animal. In particular, the present invention comprises compositions and methods for the treatment of asthma by administration of pharmaceutical preparations including D-propranolol.[0003] More than ten million persons in the United States suffer from asthma and related inflammatory lung diseases. The numbers of persons with asthma is increasing both in the United States and worldwide. The morbidity associated with asthma makes asthma a major medical condition. Asthma is the most common chronic disease of childhood and the leading cause among chronic illnesses of school absences. Asthma in humans results in an estimated 27 million patient visits, 6 million lost workdays, and 90.5 million days of restricted activity per...

AI Technical Summary

Benefits of technology

D-propranolol effectively inhibits antigen-induced bronchoconstriction and airway hyperresponsiveness, offering a safer and more effective treatment for asthma compared to existing therapies, with minimal side effects and the ability to self-administer at the onset of an attack.

Problems solved by technology

Additionally, asthma reactions are a growing problem for animals.

In particular, the horse racing industry is affected by horses that suffer from asthmatic reactions.

The histamine then attaches to receptor sites in the larger bronchi, causing irritation, inflammation and edema.

Without adequate compensation, hypoxia, and in extreme cases, respiratory acidosis may result.

The current treatments for asthma are not adequate and many have serious side effects.

Though scrupulous housecleaning and air cleansing devices can lessen the exposures to allergens, it is very difficult to eliminate all exposures to allergens.

Additionally, many of these compounds are rapidly metabolized and have very short half-lives, and thus are not effective therapy for asthma or hyperresponsiveness reactions.

The side effects of theophylline are nervousness, nausea, vomiting, anorexia, abdominal discomfort and headache.

It is difficult to reach an effective drug level that provides asthma control without triggering side effects.

These agents have tremendous toxicity in children, including adrenal suppression and reduced bone density and growth.

In all age groups, corticosteroids have numerous side effects and complications which impact major organ systems.

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