Composition containing at least one oxidation-sensitive hydrophilic active principle and at least one N-vinylimidazole polymer or copolymer useful to prevent and/or treat cutaneous signs of intrinsic ageing

a technology of n-vinylimidazole and active principle, which is applied in the field of composition comprising an oxidation-sensitive active principle, can solve the problems of easy decomposition on contact with water, conflict with the desired effect, and inability to be stable in aqueous medium, so as to achieve good cosmetic effect, prevent and/or treat the effect of ageing

Inactive Publication Date: 2003-07-03
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

0015] One object of the present invention is to provide a composition comprising an oxidation-sensitive active principle for example selected from the group consisting of ascorbic acid and its derivatives, which exhibits good cosmetic properties, both with r

Problems solved by technology

However, some of these active principles exhibit the disadvantage of being unstable in an aqueous medium and of easily decomposing on contact with water, in particular because of oxidation phenomena.
They thus rapidly lose their activity over time and this instability conflicts with the desired effectiveness.
Unfortunately, because of its chemical structure (of .alpha.-ketolactone), ascorbic acid is highly sensitive to certain environmental parameters and in particular to oxidation phenomena

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0093] Accelerated Storage Test.

[0094] The aim of this test is to study the decomposition of an oxidation-sensitive hydrophilic active principle after storing for two months at 45.degree. C. Various solutions were prepared and their compositions are collated in the following table:

1TABLE I Compositions (in Solution A water) Control Solution B Solution C Solution D Ascorbic acid 15% 15% 15% 15% Polymer 1 -- 1% -- --Polymer 2 -- -- 1% --Polymer 3 -- -- -- 1%

[0095] All the solutions are brought to pH 6 with 8.9 mol / l KOH.

[0096] The percentages of the polymers are given as active material.

[0097] Polymer 1: Vinylpyrrolidone / vinylimidazole (50 / 50) copolymer sold under the reference Luvitec VPI 55K72W of BASF (Weight-average molecular mass 1.2.times.10.sup.6).

[0098] Polymer 2: Vinylpyrrolidone / vinylimidazole (50 / 50) copolymer sold under the reference Luvitec VPI 55K8P of BASF (Weight-average molecular mass 10 000).

[0099] Polymer 3: Polyvinylpyrrolidone sold under the reference Kollidon 12P...

example 2

[0111] Observation of the Effect of the Addition of a Combination According to the Invention on the Synthesis of Tenascin and of Collagen VII:

[0112] The present example describes the effects of the addition of a combination according to the invention, comprising ascorbic acid and a polymer or copolymer according to the invention, on reconstructed skin by observation with a microscope of a skin section with immunohistochimical labelling of the proteins of tenascin and collagen VII.

[0113] 1. Preparation of the Reconstructed Skin

[0114] The reconstructed skin used is prepared according to the protocol described in Asselineau et al. (Models in Dermato. Published by Loire and Maibach, 1987, Vol III, 1-7). The modifications to this protocol are:

[0115] the use of normal adult human dermal fibroblasts in a proportion of 106 cells per equivalent dermis;

[0116] the inoculation of the keratinocytes is carried out in a proportion of 50 000 cells per ring with a diameter of 1.5 cm. The keratinocyt...

example 3

[0128] O / W Anti-Ageing Cream

[0129] The following composition is prepared in a way conventional to a person skilled in the art.

3 Water 16 g Glycerol 3 g Sorbitan tristearate 0.68 g PEG-40 stearate 1.5 g Cetyl alcohol 3 g Glyceryl stearate 2.25 g Myristyl myristate 1.5 g Ethylhexyl palmitate 1.5 g Hydrogenated polyisobutene 2.5 g Shorea robusta seed butter 1.5 g Butyrospermum parkii (shea butter) fruit 0.5 g Cyclopentasiloxane 7.5 g Phenoxyethanol 1 g Water 46.24 g Ascorbic acid 5 g Potassium hydroxide (50% solution) 3 g Vinylpyrrolidone / vinylimi-dazole copolymer 1 g

[0130] This rich and soft cream makes it possible to combat signs of intrinsic ageing and has good stability for the ascorbic acid.

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Abstract

The invention relates to a composition containing, preferably in a physiologically acceptable medium comprising an aqueous phase, at least one oxidation-sensitive hydrophilic active principle selected from the group consisting of ascorbic acid and its derivatives and at least one non-crosslinked N-vinylimidazole polymer or copolymer, the active principle and the polymer or copolymer both being in the aqueous phase, useful for preventing and/or treating cutaneous signs of intrinsic ageing.

Description

[0001] The present invention relates to a composition comprising at least one oxidation-sensitive hydrophilic active principle and at least one N-vinylimidazole polymer or copolymer in a physiologically acceptable medium comprising an aqueous phase, and its use in particular to prevent or treat cutaneous signs of intrinsic ageing. The composition is preferably a cosmetic or dermatological composition.[0002] It is known to introduce, into cosmetic compositions, various active principles intended to contribute specific treatments to the skin and / or hair. However, some of these active principles exhibit the disadvantage of being unstable in an aqueous medium and of easily decomposing on contact with water, in particular because of oxidation phenomena. They thus rapidly lose their activity over time and this instability conflicts with the desired effectiveness.[0003] Attempts have thus been made for a long time to formulate ascorbic acid or vitamin C because of its numerous beneficial p...

Claims

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Application Information

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IPC IPC(8): A61K8/00A61K8/02A61K8/03A61K8/06A61K8/11A61K8/18A61K8/30A61K8/31A61K8/33A61K8/34A61K8/36A61K8/365A61K8/368A61K8/37A61K8/40A61K8/41A61K8/42A61K8/44A61K8/46A61K8/49A61K8/55A61K8/58A61K8/60A61K8/63A61K8/67A61K8/68A61K8/72A61K8/73A61K8/81A61K8/84A61K8/90A61K8/92A61K8/96A61K8/97A61K31/375A61K31/695A61K31/787A61K45/00A61P17/16A61P43/00A61Q1/00A61Q5/08A61Q17/04A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/676A61K8/817A61Q19/08A61Q5/08A61Q19/02A61K2800/522A61P17/00A61P17/16A61P43/00A61K8/67A61K8/84A61K8/90
Inventor BIATRY, BRUNOLHEUREUX, ERIC
Owner LOREAL SA
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