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Peptide deformylase activated prodrugs

a technology of activated prodrugs and deformylase, which is applied in the direction of drug compositions, phosphorous compound active ingredients, peptide/protein ingredients, etc., can solve the problems of toxicity to non-diseased or non-infected tissue, and achieve the effect of reducing the symptoms of infection

Inactive Publication Date: 2006-03-23
BALLATORE CARLO +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They are not be appreciably activated by non-targeted enzymes, as this may result in toxicity to non-diseased or non-infected tissue.

Method used

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  • Peptide deformylase activated prodrugs
  • Peptide deformylase activated prodrugs
  • Peptide deformylase activated prodrugs

Examples

Experimental program
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Effect test

example 1

Synthetic Scheme

[0128] The following examples of the synthesis of the claimed compounds are meant to be illustrative of the synthesis of the invention and not limit the synthesis of the invention. The synthetic methods, as for example seen below, used to synthesize the compounds are known to those skilled in the art of organic and medicinal chemistry. Substitutions, modifications or additional steps used in the synthesis of the compounds of the present invention known to those skilled in the art of organic and medicinal chemistry are anticipated. See, e.g., J. March, ADVANCED ORGANIC CHEMISTRY: REACTIONS, MECHANISMS AND STRUCTURE, 4th edition (John Wiley & Sons, NY (1992)). In addition, it is understood that, for compounds having one or more asymmetric centers, both the racemic mixture and enantiomerically enhanced (i.e., one entantiomer exists in greater than 50% of the mixture) or enantiomerically pure (one enantiomer comprises 90% or more of the mixture) compounds are within the...

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PUM

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Abstract

This invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula:

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 60 / 426,771, filed Nov. 14, 2002, the contents of which hereby incorporated by reference into the present disclosure.FIELD OF THE INVENTION [0002] The present invention relates to the field of Enzyme Catalyzed Therapeutic Activation (ECTA™) therapy and in particular, ECTA therapies specific for microorganisms that express Peptide Deformylase (“PDF”). BACKGROUND [0003] Throughout this disclosure, various publications are referenced by first author and date, within parentheses, patent number or publication number. The complete bibliographic reference is given at the end of the application. The disclosures of these references are hereby incorporated by reference into this disclosure to more fully describe the state of the art to which this application pertains. [0004] Enzyme Catalyzed Therapeutic Activation (ECTA™) therapy is a novel technology ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/66C07F9/02A61K47/48
CPCA61K47/48338C07F9/4084C07F9/4006A61K47/65A61P43/00
Inventor BALLATORE, CARLOSERGEEVA, MARIA V.DOPPALAPUDI, VENKATA RAMANA
Owner BALLATORE CARLO
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