Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272

Inactive Publication Date: 2007-05-10
WYETH
View PDF25 Cites 73 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Temsirolimus exhibits cytostatic, as opposed to cytotoxic properties, and

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
  • Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
  • Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272

Examples

Experimental program
Comparison scheme
Effect test

example 1

Combination Regimen of Temsirolimus (CCI-779) and Herceptin in Trearment of Noeplasms

[0073] Dosing begins at month 1, day 1 with weekly intravenous (IV) temsirolimus and herceptin (IV) at the dosages provided below.

[0074] Temsirolimus and herceptin can be administered simultaneously, consecutively, or on alternative days.

[0075] Temsirolimus is administered IV weekly over a 30-minute period using an in-line filter and an automatic dispensing pump. Optionally, antihistamine (diphenhydramine, 25 to 50 mg IV or the equivalent) is administered about 30 minutes prior to temsirolimus infusion.

[0076] A herceptin loading dose is administered IV weekly over a 90 minute period. Weekly doses are administered, which are typically half the amount of the loading dose. For example, a 4 mg / kg loading dose is typically followed by 2 mg / kg weekly doses. These amounts may be adjusted. In one embodiment, no loading dose is required and the same dose is administered throughout the course of treatmen...

example 2

Use of a Combination Regimen of HKI-272 and Temsirolimus (CCI-779) in Treatment of Neoplasms

[0079] Dosing begins at month 1, day 1 with daily HKI-272 and weekly intravenous (IV) temsirolimus at the dosages provided below.

[0080] On month 1, day 1, HKI-272 is administered orally prior to temsirolimus. Temsirolimus is administered following HKI-272, preferably within 30 minutes.

[0081] Temsirolimus is administered IV weekly over a 30-minute period using an in-line filter and an automatic dispensing pump. Optionally, antihistamine (diphenhydramine, 25 to 50 mg IV or the equivalent) is administered about 30 minutes prior to temsirolimus infusion.

[0082] Thereafter, HKI-272 is taken orally once daily with food, preferably in the morning.

HKI-272Temsirolimus Dose(mg)(mg) 80151602524050

[0083] Dose adjustments and / or delays for HKI-272 and temsirolimus are permitted. For example, treatment may continue as described herein for six months, with daily doses of HKI-272 and weekly doses of te...

example 3

Use of a Combination Regimen of HKI-272, Temsirolimus (CCI-779), and Herceptin in Trearment of NEOPLASMS

[0084] Dosing begins at month 1, day1 with daily HKI-272 and weekly intravenous (IV) temsirolimus and herceptin (IV) at the dosages provided below.

[0085] On month 1, day 1, HKI-272 is administered orally prior to temsirolimus. Temsirolimus and herceptin are administered following HKI-272, preferably within 30 minutes.

[0086] Temsirolimus is administered IV weekly over a 30-minute period using an in-line filter and an automatic dispensing pump. Optionally, antihistamine (diphenhydramine, 25 to 50 mg IV or the equivalent) is administered about 30 minutes prior to temsirolimus infusion.

[0087] A herceptin loading dose is administered IV weekly over a 90 minute period. Weekly doses are administered, which are typically half the amount of the loading dose. For example, a 4 mg / kg loading dose is typically followed by 2 mg / kg weekly doses. These amounts may be adjusted. In one embodim...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Timeaaaaaaaaaa
Timeaaaaaaaaaa
Timeaaaaaaaaaa
Login to view more

Abstract

A combination of temsirolimus and herceptin in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of herceptin and HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing herceptin, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit under 35 USC 119(e) of US Provisional Patent Application No. 60 / 837,509, filed Aug. 14, 2005 and US Provisional Patent Application No. 60 / 733,562, filed Nov. 4, 2005.BACKGROUND OF THE INVENTION [0002] This invention relates to the use of combinations of herceptin with an mTOR inhibitor and / or HKI-272, for the treatment of neoplasms associated with overexpression or amplification of HER2. [0003] CCI-779, is rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid, an ester of rapamycin which has demonstrated significant inhibitory effects on tumor growth in both in vitro and in vivo models. This compound is now known generically under the name temsirolimus. The preparation and use of hydroxyesters of rapamycin, including temsirolimus, are described in U.S. Pat. Nos. 5,362,718 and 6,277,983. [0004] Temsirolimus exhibits cytostatic, as opposed to cytotoxic properties, and may delay the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K39/395A61K31/4745A61K31/4709
CPCA61K31/436A61K31/4709A61K31/4745A61K39/39558A61K45/06A61K2300/00A61K31/337A61P11/00A61P13/08A61P15/00A61P17/00A61P19/00A61P25/00A61P3/00A61P35/00A61P35/02A61P35/04A61P43/00A61P5/00A61P7/00A61K39/395
Inventor MOORE, LAURENCEZACHARCHUK, CHARLESRABINDRAN, SRIDHAR K.
Owner WYETH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap