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Therapy-enhancing glucan

a technology of glucan and glucan, which is applied in the field of therapy-enhancing glucan, can solve the problems of shrinkage of established tumors and inability to test in vivo the immunomodulatory effect of the tumor

Inactive Publication Date: 2008-08-14
SLOAN KETTERING INST FOR CANCER RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0087]This invention further provides a pharmaceutical composition comprising an effective amount of the above composition and a pharmaceutically acceptable carrier.

Problems solved by technology

Despite the availability of tumor-selective monoclonal antibodies and the ample supply of phagocytes / natural killers, shrinkage of established tumors following antibody treatment alone, and the acquisition of specific immunity, are not common in both preclinical models and cancer patients.
In addition, they have not yet been tested for their in vivo immunomodulatory effects in cancer models.

Method used

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  • Therapy-enhancing glucan
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Examples

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Embodiment Construction

[0051]This invention provides a composition comprising an effective amount of glucan capable of enhancing efficacy of antibodies.

[0052]In an embodiment, the antibody is a monoclonal antibody. In a further embodiment, the antibody is an antibody against cancer. In another embodiment, the antibody is a tumor-binding antibody. In a further embodiment, the antibody is capable of activating complement. In a still further embodiment, the antibody is further capable of activating the antibody dependent cell-mediated cytotoxicity.

[0053]In an embodiment, the antibody is directed at the epidermal growth factor receptor. In a further embodiment, the antibody is 528 or C225.

[0054]In another embodiment, the antibody is directed to a ganglioside. In a further embodiment, the ganglioside is GD3. In a still further embodiment, the antibody is R24.

[0055]In a separate embodiment, the ganglioside is GD2. In a further embodiment, the antibody is 3F8.

[0056]In an embodiment, the antigen recognized by the...

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Abstract

This invention provides a composition comprising an effective amount of glucan capable of enhancing efficacy of antibodies. This invention further provides the above compositions and a pharmaceutically acceptable carrier. This invention also provides a method for treating a subject with cancer comprising administrating the above-described composition to the subject. This invention provides a composition comprising effective amount of glucan capable of enhancing efficacy of vaccines. This invention also provides a method of treating a subject comprising administrating the above pharmaceutical composition to the subject. This invention provides a composition comprising effective amount of glucan capable of enhancing efficacy of natural antibodies. This invention provides a composition comprising effective amount of glucan capable of enhancing host immunity. This invention also provides a composition comprising effective amount of glucan capable of enhancing the action of an agent in preventing tissue rejection.

Description

[0001]This application is continuation of U.S. Ser. No. 10 / 621,027, filed Jul. 16, 2003, which is a continuation-in-part of International Application No. PCT / US02 / 01276, Filed 15 Jan. 2002, claiming the benefit of U.S. Ser. No. 60 / 261,911, filed on 16 Jan. 2001, and the contents of the preceding applications are incorporated by reference here into this application in their entirety.[0002]Throughout this application, various references are cited. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains.BACKGROUND OF THE INVENTION[0003]Monoclonal antibodies (MoAb) selective for tumors have therapeutic potential.1,2 The introduction of hybridoma technology by Kohler and Milstein in 19753 and the advances in molecular biologic techniques have greatly expanded the potential of MoAb in human cancers. Anti-CEA antibody in colorectal cancer,4 anti-CD20 antibod...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/395A61K31/715A61P43/00A61K31/739A61K39/44
CPCA61K31/715A61K2039/55583A61K31/739A61K39/39A61K39/39541A61K39/39558A61K39/44A61K47/36A61K31/716C08B37/0024A61K2300/00A61P35/00A61P37/04A61P43/00
Inventor CHEUNG, NAI-KONG V.
Owner SLOAN KETTERING INST FOR CANCER RES
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