Rhesus monkey erythrocyte adsorber

Abstract

The invention relates to a rhesus monkey erythrocyte adsorber, belonging to the field of medicine science. According to the rhesus monkey erythrocyte adsorber, rhesus monkey erythrocytes replace human Rh positive O erythrocytes, the rhesus monkey erythrocytes are washed by 4 DEG C normal saline and 37 DEG C normal saline, so that immune antibodies or natural antibody attaching to the surfaces of the erythrocytes can be removed, after antigenicity detection, cell sediment is added into a cylindrical adsorber made of a material with high biocompatibility till 4 / 5 of the volume is occupied, then 3.5% of mannitol erythrocyte preserving fluid is added, so that the concentration of the erythrocyte achieves 80%, shaking is carried out gently for uniform mixing, the opening is sealed, and the product is stored at 4 DEG C for regular use, wherein a screen is arranged at the opening of a purifier, so that a line of defense for preventing cell debris from being filtered out is formed, after the plasma is filtered, Rh antibodies are combined with Rh positive rhesus monkey erythrocytes to form a fixed compound, the broken erythrocyte debris and the macromolecular compound combined with the broken erythrocyte debris are blocked by the screen of the purifier, and the plasma with morbid substance removed is filtered by the purifier and then conveyed back, so that the purpose of treating blood-group-incompatible haemolytic diseases is achieved by eliminating Rh antibodies of the plasma.

Description

technical field [0001] The invention relates to a rhesus monkey red blood cell adsorber in the medical field, which is mainly used for removing anti-fetal red blood cell antibodies and red blood cell lysates in the blood plasma of pregnant women with maternal-fetal Rh incompatibility. Background technique [0002] The fetus inherits half of the genetic components of the father and half of the mother, and the fetal red blood cells can carry antigens from the father, showing that the blood type of the fetus is different from that of the mother. When the fetal red blood cells enter the mother's blood circulation, the mother's immune system is induced to produce antibodies, and the antibodies pass through the placenta and enter the fetal blood circulation system, combining with fetal red blood cells, causing fetal red blood cells to be destroyed, resulting in maternal-fetal blood group incompatibility hemolytic disease in fetuses and newborns . [0003] There are 26 human eryth...

AI Technical Summary

Problems solved by technology

However, plasma exchange can only remove part of the antibodies in the blood, and cannot stop the continuous production of antibodies, nor can it reverse the existing maternal-fetal blood group incompatibility hemolytic disease. It needs continuous plasma exchange to be effective. Pregnant women who had fetal hydrops two weeks ago, or whose spouses are homozygous for the pathogenic antigen, especially while removing part of the pathogenic antibody, also removed a large amount of plasma (multiple beneficial components), although the replacement fluid Supplementation has been made, but the removed plasma and its various beneficial components cannot be completely supplemented, and the replacement fluid for the replacement is large and expensive. Supplementing allogeneic plasma is prone to various side effects such as infectious diseases and infusion reactions, which limits plasma exchange. the general development of

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