Dispensing device

Abstract

A dispensing device and a storage device for dispensing a formulation as a spray. The storage device has multiple separate and pre-metered doses of the formulation in receptacles or cavities. In order to allow a very compact arrangement, the receptacles or cavities are arranged in a first group and a second group axially offset, and preferably, forming a double ring arrangement, and the storage device is rotatable and axially moveable for dispensing the doses one after the other.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention relates to a dispensing device for preferably dispensing a medical formulation, in particular containing or consisting of a drug or mixture of drugs, and to a storage device for a preferably medical formulation, in particular, containing or consisting of a drug or mixture of drugs.[0003]2. Description of Related Art[0004]Drugs delivered through dispensing devices, in particular inhalers, are intended to optimally target specific sites in the pulmonary system. These sites include the nasal passages, the throat, and various locations within the lungs, such as the bronchi, bronchioles and alveolar regions. The ability to deliver drugs to a target area depends inter alia on the aerodynamic sizes of the particles or droplets. As currently believed to be understood, particles having an aerodynamic diameter of less than 2 micrometer are considered to be potentially optimal for deposition in the alveolar r...

AI Technical Summary

Benefits of technology

[0014]The present invention relates to the dispensing of a preferably medical formulation. The term “formulation” relates in particular to powder, but may include or relate to liquid as well. Consequently, the fine “particles” may be either solid or liquid. The term “liquid” has to be understood preferably in a broad sense covering inter alia solutions, suspensions, suslutions, mixtures thereof or the like. More particularly, the present invention relates to the dispensing of formulations for inhalation, such as medical formulations containing or consisting of at least one drug. In the present invention, the desired spray plume characteristics include preferably a small particle size, a high fraction of drug particles with a diameter of preferably 6 micrometer or less, a low propagation velocity and / or a long duration of spray generation and possible inhalation.

Problems solved by technology

The problem with passive inhalers is that the inhalable fraction, or the proportion of powder that actually enters the lungs, is largely dependent on the breathing of the patient.

The lactose and / or active drug(s) tend to absorb humidity from the atmosphere, which makes them stick together and difficult to transfer and de-agglomerate.

It is difficult to empty the respective pocket completely during a dispensing operation.

Incomplete emptying results in decreased delivery efficiency.

Some powder may be lost in the inhaler and not dispensed because the known solutions require relatively long paths for the powder until the powder reaches a nozzle and is actually dispensed.

This might reduce the delivery efficiency further.

In addition, de-agglomeration of the powder is difficult.

This does not allow a well-defined discharge and deagglomeration of the medicaments.

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