Method and apparatus for acquiring blood for testing

Inactive Publication Date: 2013-05-09
NEOTERYX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]A device is provided that is suitable as a quantitative sampling tool for biological fluids, preferably blood. It is designed for samples to be easily dried, shipped, and then later analyzed. The device includes an absorbent probe, preferably smaller at a distal end and larger at a fastening end, has its fastening end fastened to a holder and its other, distal end free to contact a fluid to be absorbed, such as blood. The holder allows easy manipulation of the absorbent probe. The absorbent probe is placed against a blood s

Problems solved by technology

This sample size limits the number of time-points which can be taken from a single animal due to the limited blood volume of small animals such as rats.
Moreover, there are high costs involved with the freezing transportation and processing of whole blood.
When a card is used for direct sample collection from a wound (e.g. a neonatal heel prick or a finger prick) there is risk for collection of too much blood on the card which will lead to an overlapping of samples from the spots.
This will lead to difficulty in obtaining a sub-punch from the card that is representative of the entire spot.
Additionally, various chemical treatments of card materials can lead to separation of the PCV and serum during the drying process leading to non-homogenous sampling.
There are drawbacks, however, to the downstream processing of blood spots.
It is difficult to sample precise volumes using traditional glass capillaries, particularly directly from an animal or patient blood bolus.
While use of micropipettes (15 ul sample) can successfully create accurate spot volumes in carefully controlled settings, in practice these have proven to be unreliable.
Another drawback with the punching technique is that it relies on a constant sample viscosity in the expect

Method used

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  • Method and apparatus for acquiring blood for testing
  • Method and apparatus for acquiring blood for testing
  • Method and apparatus for acquiring blood for testing

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Example

[0068]Referring to FIGS. 2-3 and 8, a collection device 10 for collecting various fluids, especially biological fluids and preferably blood, is provided. The device 10 has a sampling end 12 and a holder 14 joined at a juncture 16. The sampling end 12 advantageously comprises an absorbent probe 18 made of a material that wicks up or otherwise absorbs a sample 20 from a fluid source 22, which preferably comprises body fluids and more preferably is blood from a finger-prick or cut 23. The holder 14 may have the absorbent material 18 held in one end, with an opposing end either closed, or preferably open and hollow and optionally configured to allow it to mate with a pipette tip. Releasable adhesives can be used to more securely fasten the parts, but it is believed preferably to force the absorbent probe 18 into a slightly smaller opening in the holder 14 (pipette tip) so the interference fit between the opening and absorbent probe 18 hold the parts together. The device 10 is suitable a...

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PUM

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Abstract

A blood sampling device is provided having holder with a manipulating end and an absorbent probe on the opposing end. The probe is of hydrophilic polymer sized to directly absorb a predetermined volume of up to about 30 microliters of blood. Ribs on the holder position the probe within a compartment of a container to prevent contact with the container. The ribs also position the probe within extraction wells.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The application claims the benefit under 35 U.S.C. §119(e) to Provisional Patent Application No. 61 / 555,956 filed Nov. 4, 2012, titled METHOD AND APPARATUS FOR ACQUIRING BLOOD FOR TESTING, the entire contents of which are incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]This application relates to a method apparatus for sampling blood for use in testing for either research or for diagnostic use.[0003]Multiple blood samples are used for clinical trials for pharmacokinetic analyses. These samples are often collected by sampling whole blood freezing and then processing the frozen blood later. Frozen blood requires a 200-250 ul sample of blood to be taken. This sample size limits the number of time-points which can be taken from a single animal due to the limited blood volume of small animals such as rats. Furthermore small volumes of blood samples are desired when dealing with critically ill patients. Moreover, there are hig...

Claims

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Application Information

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IPC IPC(8): A61B5/15B01L3/00
CPCA61B5/150358B01L3/50B01L3/0275B01L3/5023B01L3/5085B01L9/543A61B5/150755B01L2300/105G01N2001/4027A61B5/150022A61B5/150305A61B5/150343A61B5/150351B01L2200/0678A61B5/150213B01L2300/069
Inventor RUDGE, JAMESRAHN, PETERWELSH, EMMETGUO, YIBOSANCHEZ, CARL
Owner NEOTERYX
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