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Lawsonia vaccine and methods of use thereof

a technology of lawsonia and vaccine, applied in the field of improved vaccine methods, can solve the problem of quick emergence of ileitis susceptibleness, and achieve the effect of increasing the protection of swine against ileitis, safe and effective delivery, and immunizing them against ileitis

Inactive Publication Date: 2013-06-27
BOEHRINGER LNGELHEIM VETMEDICA GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The method provides significant protection against ileitis in piglets, reducing gross pathology and disease severity, and is safe for both sows and piglets, with maternal immunity not interfering with the piglets' vaccination.

Problems solved by technology

Unless vaccinated however, they quickly become susceptible to the disease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051]This example evaluated the efficacy of a Lawsonai vaccine in three-week old piglets born from Lawsonia-vaccinated and non-vaccinated sows and determined whether or not sow vaccination caused maternal immune interference that prevented a response to piglet vaccination, as measured by a reduction in the induction in disease following virulent pure culture challenge of both vaccinated and non-vaccinated piglets. The primary study parameters used to measure efficacy were macroscopic and microscopic lesions of the ileum and colon. Additionally, this example evaluated the Lawsonai vaccine for safety issues when administered to pregnant sows during the second and third stages of gestation following single and repeated dose administration.

Materials and Methods

[0052]In a blinded study, sixteen healthy, pregnant, and Lawsonai sero-negative sows were obtained and randomly divided into 2 groups, A and B, each having 8 sows. Group A received 3 doses of Enterisol Ileitis B3903 by oral drenc...

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PUM

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Abstract

The present invention provides improved vaccination methods for increased protection against ileitis. The methods provide for the vaccination of young animals, preferably piglets, between 10 and 26 days of age, vaccination of pregnant sows during the second or third stages of gestation, and a combination of these methods. Vaccination of the pregnant sows can occur using repeated and / or high doses of Lawsonai antigen prior to farrowing.

Description

RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Patent Application Ser. No. 60 / 699,946, filed on Jul. 15, 2005, the teachings and contents of which are incorporated by reference herein.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention is broadly concerned with improved vaccination methods for immunization against porcine proliferative enteritis, known as ileitis, which is caused by an obligate intracellular bacterium Lawsonia intracellularis (Lawsonai or L. intracellularis). Specifically, the invention provides methods for providing increased protection against L. intracellularis by vaccinating pregnant sows; by vaccinating pregnant sows and then subsequently vaccinating their young piglets within about three weeks after birth; and by vaccinating young piglets within 25 or 26 days of birth, respectively.[0004]2. Description of the Prior Art[0005]Porcine proliferative enteritis (PPE), is a naturally occurring diseas...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/02
CPCA61K39/105A61K2039/522A61K39/0208A61K2039/545A61K2039/552A61K2039/542A61P31/04A61K39/02
Inventor KROLL, JEREMY J.ROOF, MICHAEL B.
Owner BOEHRINGER LNGELHEIM VETMEDICA GMBH
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