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Biocompatible Carrier Containing A Bioadhesive Material

a bioadhesive material and carrier technology, applied in the direction of antibody medical ingredients, catheters, anhydride/acid/halide active ingredients, etc., can solve the problems of insufficient patient treatment effect, adversely affecting healthy tissues, and insufficient absorption of drugs into and through target tissue, so as to reduce, delay or eliminate the resting of blood vessels , to reduce, delay or eliminate the resting of blood vessels

Inactive Publication Date: 2014-08-28
ABBOTT CARDIOVASCULAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The bioadhesive carrier ensures more effective and prolonged delivery of therapeutic agents to the target area, reducing side effects and improving treatment outcomes by maintaining higher drug concentrations at the site of action.

Problems solved by technology

Because of the necessity to use large quantities of the drug, systemic administration can produce toxic side effects for the patient, and can adversely affect healthy tissues which need not be exposed to the drug.
The absorption of drugs into and through the tissue of the target area is often inadequate for the effective treatment of the patient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011]As used herein, “abnormal” or “inappropriate” proliferation means division, growth or migration of cells occurring more rapidly or to a significantly greater extent than which typically occurs in a normally functioning cell of the same type, i.e., hyperproliferation.

[0012]As used herein, “analogs” or “derivatives” refer to a structural or functional variation of a therapeutic compound or an active agent, including fragments, derivatizations, or other chemical modifications, so long as the compound retains its characteristic biological activity.

[0013]As used herein, “bioadhesive” or “bio-adhesive” composition, formulation, material and the like refer to a naturally occurring or synthetic compound that adheres, binds or interacts with a biological tissue, including a lumen wall such as a vascular wall. The bioadhesive used with the carrier of the invention results in prolonging the residence time of the therapeutic substance at the site of contact. It is understood that the bioa...

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PUM

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Abstract

A biocompatible carrier for delivery of a therapeutic substance or an active agent is disclosed. The carrier contains a bioadhesive material allowing for increased residence time of the active agent at the treatment site.

Description

CROSS-REFERENCE TO RELATED CASES[0001]This application is a division of U.S. patent application Ser. No. 10 / 098,686, filed on Mar. 15, 2002, which is incorporated by reference herein in its entirety, and expressly including any drawings, and is incorporated by reference for all purposes.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]This invention relates to a biocompatible carrier containing an active ingredient for introducing the active ingredient to a target cell population, such as smooth muscle cells, requiring modulation to ameliorate a diseased state such as restenosis. More particularly, the invention is directed to a polymeric matrix that contains a bioadhesive formulation for specific or non-specific binding to a biological target.[0004]2. Description of the Background[0005]Systemic administration of a drug for the treatment of a disease, such as a tumor or vascular restenosis, can be accomplished by administering large quantities of the drug orally or pa...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/48A61K9/14
CPCA61K9/4891A61K9/48A61K9/14A61K38/12A61K31/19A61L29/08A61L29/16A61M25/10
Inventor ROORDA, WOUTER E.
Owner ABBOTT CARDIOVASCULAR