Bicyclic cyclohexose nucleic acid analogs

a technology of cyclohexose and bicyclic nucleic acids, applied in the field of new products, can solve problems such as loss of the normal function of the target rna
US20150191727A1Inactive Publication Date: 2015-07-09IONIS PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
IONIS PHARMA INC
Publication Date
2015-07-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides bicyclic cyclohexose nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.
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Description

FIELD OF THE INVENTION

[0001] Provided herein are novel bicyclic nucleoside analogs and oligomeric compounds and compositions prepared therefrom. More particularly, bicyclic nucleoside analogs are provided wherein the naturally occurring pentofuranose ring is replaced with a cyclohexyl ring that comprises one ring heteroatom and a bridge making the ring system bicyclic. In certain embodiments, the oligomeric compounds and compositions of the present invention are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The oligomeric compounds provided herein are also expected to be useful as primers and probes in diagnostic applications.SEQUENCE LISTING

[0002] The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled CHEM0030USC1SEQ_ST25.txt, created on Mar. 18, 2015 which is 8 Kb in size. The information in the electronic format of the sequence listing...

Claims

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