Coagulation Factor-Targeting to TLT-1 on Activated Platelets

Abstract

The current invention relates to: procoagulant proteins which may, for example, be fusion proteins or chemical conjugates; methods of producing said procoagulant proteins; polynucleotides that encode said fusion proteins and cells that expresses them. Furthermore, the current invention relates to procoagulant proteins for use as a medicament. Individuals that have a coagulopathy, such as haemophilia A and B with or without inhibitors, may be treated with the procoagulant proteins of the current invention.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 13 / 982,360 filed Jul. 29, 2013 which is a 35 U.S.C. §371 National Stage application of International Application PCT / EP2012 / 053619 (WO 2012 / 117091 A1), filed Mar. 2, 2012, which claimed priority of European Patent Application 11156682.4, filed Mar. 2, 2011; this application claims priority under 35 U.S.C. §119 of U.S. Provisional Application 61 / 449,254; filed Mar. 4, 2011; the contents of all above-mentioned applications are incorporated herein by reference.FIELD OF THE INVENTION[0002]The current invention relates to procoagulant proteins, polynucleotides that encode procoagulant fusion proteins, cells that express procoagulant fusion proteins, a process for preparing procoagulant proteins and uses of said procoagulant proteins.INCORPORATION-BY-REFERENCE OF THE SEQUENCE LISTING[0003]In accordance with 37 C.F.R. §1.52(e)(5), Applicants enclose herewith the Sequence Listing for...

AI Technical Summary

Problems solved by technology

In subjects with a coagulopathy, such as human beings with haemophilia A, B or C, various steps of the coagulation cascade are rendered dysfunctional due to, for example, the absence or insufficient presence of a functional coagulation factor.

Such dysfunction of one part of coagulation results in insufficient blood coagulation leading to spontaneous bleeds e.g. in joints and potentially life-threatening bleeding.

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