Hemodynamic parameter (Hdp) monitoring system for diagnosis of a health condition of a patient

Inactive Publication Date: 2016-11-03
THERABIONIC INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0008]A hemodynamic parameter (Hdp) monitoring system for diagnosing a health condition of a patient, for establishing Hdp marker values or Hdp surrogate marker values for purposes of comparison with Hdp values of a patient is provided. An Hdp monitor senses, measures, and records Hdp values exhibited by the patient during a basal or non-exposure period and furthermo

Problems solved by technology

This disclosure, however, does not contemplate or suggest employing measured Hdp values as a means f

Method used

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  • Hemodynamic parameter (Hdp) monitoring system for diagnosis of a health condition of a patient
  • Hemodynamic parameter (Hdp) monitoring system for diagnosis of a health condition of a patient
  • Hemodynamic parameter (Hdp) monitoring system for diagnosis of a health condition of a patient

Examples

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example 1

[0040]Exemplary of the nine different Hdp values recorded during 16 consecutive heart beats are set forth below:

TABLE 1Hemodynamic Parameter Values RecordedBeatRRIHRsBPdBPmBPPPSVCOTPR934976.042 61.473112.32263.72584.55648.59757.3923.5281849.328935993.37560.4112.71663.78985.87648.927 52.5713.1752087.9949361010.66759.367113.36961.485.03551.96959.2483.5171865.839937633.042 94.78110.84770.26682.04240.58158.3035.5261144.2839381249.70848.011111.51557.73682.34153.77961.0382.9312165.934939990.41760.581 112.16661.94582.06550.221 64.365 3.8991622.152940992.37560.461 111.23859.975 82.67151.263 63.3893.8331663.03494193764.034 108.90460.4979.80448.41463.4314.0621512.7194295362.959107.37762.1180.93345.26764.352 4.0521538.824943974.66761.56111.21962.06383.4849.15667.0784.1291559.211944696.375 86.16110.61467.45984.90643.15565.595.6511159.479451214.33349.41110.8457.56281.26153.27865.0463.2141948.051946985.7560.867 109.05262.014 79.85547.038 66.3794.041521.7759471002.66759.84111.22261.649 83.61649.57...

example 2

[0042]The following Table 2 is exemplary Principal Component (PC) values, representative of a multiple number of sensed and recorded hemodynamic parameter values for each of the nine values of a number of patients. The PC representative values are divided into three groups: Pressure, Flow and Beat for three groups each of 8 patients, respectively 8 patients with hepatocellular carcinoma (HCC), 8 patients with breast cancer, and 8 healthy controls for simplifying comparisons of PC Hdp values between patients with a diagnosis of HCC or breast cancer and healthy controls. Also included in the following Table is reference to X and Y canonical coordinates obtained by the Fisher's discriminant analysis, representative pressure, flow and beat PC values of Hdp's exhibited by patients before exposures or applications of EM AM signals:

TABLE 2Diagnosis based on Hemodynamic parameter (Hdp) linear discriminate and PC AnalysesCoordinateCoordinatePressure principal componentsFlow principal compone...

example 3

[0044]The following Table 3 is exemplary discrimination by analytical geometry using canonical coordinates and vectors obtained from PC values, representative of a multiple number of sensed and recorded hemodynamic parameter values for each of the nine values of a number of patients. The PC representative values are divided into three groups, Pressure, Flow and Beat for three groups each of the patients, respectively with HCC, patients with breast cancer, and healthy controls. For determining the generalized squared distance to d_group of values using linear discriminant function of geometric parameters, the distinct group of patients based on their diagnosis is identified:

TABLE 3Diagnosis based on hemodynamic parameter (Hdp), lineardiscriminant and geometry analysesd_groupCancerHealthyCancer0120.49729Healthy120.497290LDA constant−0.89418−68.98654area of triangle0.01710.33941Apotema P-B−0.15385−3.18876Apotema B-F0.408582.7007Apotema F-P−0.003240.65841Area of circle−0.001−0.0002086d_...

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Abstract

A hemodynamic parameter (Hdp) monitoring system for diagnosing a health condition of a patient and for establishing Hdp marker values or Hdp surrogate marker values for purposes of comparison with Hdp values of a patient is provided. An Hdp monitor senses, measures, and records Hdp values exhibited by the patient during a basal or non-exposure period and furthermore Hdp values exhibited by the patient during or after an exposure period during which the patient is exposed to low-energy electromagnetic output signals. An electrically-powered generator is adapted to be actuated to generate said low-energy electromagnetic carrier output signals for exposing or applying to the patient such output signals during said exposure period.

Description

FIELD OF THE INVENTION[0001]This invention relates to a hemodynamic parameter (Hdp) monitoring system for diagnosis, more particularly involving a monitor able to sense and monitor various specified Hdp values and providing recorded values thereof. The recorded specified Hdp values include values required for purposes of performing diagnoses in terms of the invention.BACKGROUND OF THE INVENTION AND STATE OF THE ART[0002]Various Hdp monitors are available in the art. Such monitors are generally employed to sense and monitor various Hdp values, usually for purposes of diagnosing cardiovascular conditions of a patient. Hdp measurements performed, generally in conjunction with an electrocardiogram (ECG), might include measurements of stroke volume (SV), stroke index (SI) and cardiac output (CO). Such measurements are indicated for the diagnosis and therapy of patients suffering from cardiac conditions such as heart failure, hypertension, coronary artery disease, pericardial disease, obs...

Claims

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Application Information

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IPC IPC(8): A61B5/0265A61B5/029A61B5/0456A61B5/021A61B5/352A61B5/361A61B5/363A61B5/364A61B5/366
CPCA61B5/0265A61B5/0456A61B5/029A61B5/021A61B5/02007A61B5/0245A61B5/352A61N5/022A61N5/025A61N1/403A61B5/02108A61B5/02141A61B5/0255
Inventor COSTA, FEDERICO PEREGO
Owner THERABIONIC INC
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