Methods for producing a potentiator of Bacillus pesticidal activity

US6268181B1Inactive Publication Date: 2001-07-31VALENT BIOSCI

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The factor potentiates the pesticidal activity of a Bacillus related pesticide and may have a molecular weight of from about 350 to about 1200 or in a specific embodiment from about 350 to about 700.

The factor potentiates the pesticidal activity of a Bacillus related pesticide at least about 1.5 fold to optionally about 1000 fold, preferably from about 100 fold to about 400 fold. In a specific embodiment, the factor potentiates the pesticidal activity of a Bacillus thuringiensis delta-endotoxin including but not limited to a CryI (including but not limited to CryIA, CryIB, and CryIC), CryII, CryIII, CryIV, CryV, or CryVI protein in full-length form or a proteolytically processed, truncated form, from about 1.5 fold to about 1000 fold. In a most specific embodiment, the factor potentiates a B.t. delta-endotoxin from about 100 fold to about 400 fold. The factor may also potentiate the pesticidal activity of a chemical pesticide and / or a virus with pesticidal properties.

The factor may ...

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Abstract

This invention is directed to a method for obtaining a factor which potentiates the pesticidal activity of a Bacillus related pesticide, a chemical pesticide and / or a virus with pesticidal properties.

Description

1. FIELD OF THE INVENTIONThe invention is related to a method of obtaining and identifying a factor which potentiates the pesticidal activity of a Bacillus related pesticide, a chemical pesticide and / or a virus with pesticidal properties.2. BACKGROUND OF THE INVENTIONEvery year, pests detrimental to agriculture, forestry, and public health cause losses in the millions of dollars. Various strategies have been used to control such pests.One strategy is the use of chemical pesticides with a broad range or spectrum of activity. However, there are a number of disadvantages with using chemical pesticides. Specifically, because of their broad spectrum of activity, these pesticides may destroy non-target organisms such as beneficial insects and parasites of destructive pests. Additionally, chemical pesticides are frequently toxic to animals and humans. Furthermore, targeted pests frequently develop resistance when repeatedly exposed to such substances.Another strategy involves the use of bi...

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Application Information

Patent Timeline

31 Jul 2001

Publication

US6268181B1

IPC: A01N47/28; A01N63/02; A01N63/00; C07C275/00; C07C275/16; A01N63/23; C12P21/04

CPC: A01N47/28; A01N63/00; A01N63/02; C07C275/16; A01N2300/00; A01N63/23

Inventors: MANKER, DENISE CAROL; LIDSTER, WILLIAM D.