New [1,2,3]-thiobiazole derivative and its synthesis and use

Abstract

The present invention provides one kind of 1, 2, 3-thiobiazole-5-formamide compounds and their synthesis process and pesticide bioactivity screening. The screening system includes the determination of tobacco mosaic disease resisting activity, tobacco mosaic disease virus resistance inducing activity, and pesticidal and fungus-inhibiting activity. The related compounds are 1, 2, 3-thiobiazole-5-formamide derivatives with the general expression as shown, and include 7 hetero cycle containing 1, 2, 3-thiobiazole-5-formamide derivatives, 2 benzene ring containing 1, 2, 3-thiobiazole-5-formamide derivatives, and 2 aliphatic radical containing 1, 2, 3-thiobiazole-5-formamide derivatives.

Description

technical field [0001] The technical scheme of the present invention relates to heterocyclic compounds containing 1,2-oxadiazole, in particular to [1,2,3]thiadiazole derivatives. Background technique [0002] Thiadiazole derivatives are important pharmaceutical and pesticide intermediates, thiadiazoles include [1,2,3]thiadiazole, [1,2,4]thiadiazole, [1,2,5]thiadiazole , [1,3,4] thiadiazole 4 isomers, each isomer has a commercial variety in pesticides, the most widely used is the derivative of [1,3,4] thiadiazole , [1, 2, 3] thiadiazole derivatives reported relatively few biological activities, but [1, 2, 3] thiadiazole derivatives have been used in agriculture, industry and medicine, because [1 , 2,3] The thiadiazole ring is the only one among several isomers that can easily generate N through pyrolysis and photolysis 2 The isomers of [1, 2, 3] thiadiazoles are therefore becoming research hotspots in the era of increasing environmental protection concerns. [1,2,3]-Thiadia...

AI Technical Summary

Problems solved by technology

[0011] Among the [1,2,3]thiadiazole derivatives disclosed in domestic and foreign patent documents, amide derivatives have been reported, but there are few reports on the screening of such compounds to induce disease resistance activity. In order to further search for more For novel TDL derivatives with high inducing activity, we fit different types of novel [1, 2, 3] thiadiazole derivatives that have not been reported in literature and patents, and screen for inducing disease resistance and other biological activities

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