Use of human homology cassette gene LHX4 in preparing medicine for treating phaeochromocytoma

A homeobox gene, pheochromocytoma technology, applied in the field of gene use, can solve the problems such as the inability to further study the function and the reduction of the expression level.
CN100335137CInactive Publication Date: 2007-09-05INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
Publication Date
2007-09-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses the application of human homology cassette gene LHX4 in preparing medicine for treating phaeochromocytoma. Through retroviral vector, human LHX4 gene is transduced into phaeochromocytoma cell PC12. Human LHX4 gene has functions of inhibiting the extracorporeal multiplication of PC12 and promoting the differentiation toward neure and axon growth of PC12, so that it may be used in preparing medicine for treating phaeochromocytoma.
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Description

technical field

[0001] The present invention relates to the use of a gene, in particular to the use of human homeobox gene LHX4 in preparing pheochromocytoma therapeutic drugs. Background technique

[0002] Homeobox gene (homeobox gene) is a class of genes discovered in Gehring Laboratory in Switzerland in 1983. They share a 180-base-pair, highly conserved homeobox sequence at the 3′ end of the gene exon. Hence the name, the expression product of homeobox gene is an important type of transcription factor, the main control gene of development, and plays an important role in the regulation of embryonic development. The protein translated from this sequence is more conservative and rich in basic amino acids, so it is called homeodomain. LIM homeobox gene (LIM homeobox gene) belongs to the homeobox gene family, it not only has a homeobox structure, but also contains two LIM domains rich in cysteine ​​and histidine. The name of the LIM domain is derived from the acronym of the ...

Claims

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