Chalcomoracin, a biologically active monomer component in mulberry leaves based on ultraviolet induction, and its preparation method and use

A biologically active and mulberry leaf technology, which is applied in the field of preparation of the monomer component chalcomoracin, can solve problems such as the preparation process is not clear, and achieve the effect of reasonable technical route, reasonable economy, and anti-radiotherapy sensitization of malignant tumors
CN108250167BInactive Publication Date: 2020-05-22ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2020-05-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a biological activity monomer ingredient chalcomoracin inside mulberry leaves based on ultraviolet induction and a preparation method and application thereof. The preparation method comprises the following steps: (1) selecting freshly picked mulberry leaves, drying and smashing through ultraviolet induction; (2) carrying out degreasing, extraction and concentration steps onthe smashed dry mulberry leaves to obtain a total extract; and (3) carrying out silicagel column separation and Sephadex LH-20 gel column purification on the total extract to obtain a chalcomoracin pure product, and adopting an HPLC analytical method for measurement, wherein the purity of the pure product is greater than 85%. The method for preparing chalcomoracin from the mulberry leaves after ultraviolet induction provided by the invention is economical and reasonable in technical route, and the obtained product is controllable in quality; and the chalcomoracin has obvious malignant tumor resistance and radiation oncology sensibilization, is novel and unique in mechanism of action, and can be applied to preparing novel anti-tumor medicine.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to a preparation method and application of chalcomoracin (CMR), a monomer component in mulberry leaves, based on ultraviolet induction. Background technique

[0002] Mulberry (Morus alba L.) is a deciduous tree or shrub of the genus Moraceae, and its leaves, twigs, root bark, and fruit ears can be used as medicine. Mulberry leaves are frost-dried leaves of the Moraceae plant mulberry. Mulberry leaves are bitter, cold, and return to the lung and liver meridians. They have the effects of dispelling wind and heat, clearing the liver and improving eyesight. , hot cough, conjunctival congestion, swelling and pain, dark eyes embolism. In addition, mulberry leaves are also the main food source for silkworms because of their large leaves and thick and juicy flesh. Mulberry likes a warm and humid climate, is resistant to cold and drought, and is planted all over the country, mostly i...

Claims

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