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Bacillus subtilis, composite preparation, and method for preparing the composite preparation

A technology of Bacillus subtilis and bacterial strains is applied in the field of preparation of compound preparations, which can solve the problems of no antagonism, no antibiotic resistance, etc., and achieve the effects of reducing drug residues, improving sensitivity, and improving safety.

Inactive Publication Date: 2007-12-05
烟台绿云生物工程研究院有限公司
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Problems solved by technology

But its weak point is that there is no antagonism to Salmonella D enteriditis, Staphylococcus aureus, StreptococcusPyogenes, Proteus mirabili, Proteus Vulgaris, Pseudomonas aeruginosa, Klebsillapneumoniae, and Bacillus subtilis BS-3 does not have antibiotic resistance, so whether the preparation can be used with antibiotics Simultaneous use is under study

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  • Bacillus subtilis, composite preparation, and method for preparing the composite preparation

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[0082] Composition of compound preparations. Based on Bacillus subtilis LY-35 and E. Coli, Salmonella D enteriditis, Staphylococcus aureus, Streptococcus Pyogenes, Proteus mirabili, Proteus Vulgaris, Pseudomonas aeruginosa, and Klebsillapneumoniae phages with typical morphology, culture, and biochemical characteristics, four composites were prepared. Preparations, for the convenience of use and transportation, the compound preparations are concentrated preparations.

[0083] The first preparation contains

[0084] 1. The number of viable bacteria of Bacillus subtilis LY-35 in one milliliter of compound preparation is 1×10 9 .

[0085] 2. The phage titer of one milliliter compound preparation E.Coli, Salmonella D, enteriditi, Staphylococcus aureus, Streptococcus Pyogenes, Proteus mirabilis, Proteus Vulgaris, Pseudomonasaeruginosa, Klebsilla pneumoniae is 10 6 (ten-fold serial dilution method).

[0086] 3. Enzyme inhibition stabilizer: 0.5% EDTA (ethylenediaminetetraacetic a...

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Abstract

This invention describes a bacillus subtilis and the process for preparing its compound pharmaceutics. The bacillus subtilis is conserved at China General Microbiological Culture Collection Center of China Committee of Culture Collection for Microorganisms, the name is: Bacillus subtilis LY-35 and the conservation number is: CGMCC No. 1222. The pharmaceutics is a compound of the bacteriophages of such pathogens as bacillus subtilis, Staphylococcus, Streptocoaus, colibacillus, proteus, pseudomonas, salmonella, shigella, pasteurella and klebsiella. The pharmaceutics can prevent and treat the diseases caused by pathogens, and can be a non-polluted, high therapeutic effectiveness and safe substitute for antibiotics.

Description

technical field [0001] The invention relates to a bacillus subtilis, a compound preparation prepared by using the strain, and a preparation method of the compound preparation. Background technique [0002] In recent years, with the development of my country's aquaculture industry and the improvement of intensification, bacterial diseases have become an obstacle restricting the further development of aquaculture industry. Especially suppurative inflammatory diseases caused by opportunistic pathogenic bacteria present in large quantities in the environment such as Staphylococcus, Streptococcus, Escherichia coli, Proteus, Pseudomonas, Salmonella, Shigella, Pasteurella and Klebsiella Widely popular. Due to the lack of scientific management and the abuse of antibiotics, not only the micro-ecological balance of the normal flora has been destroyed, but also a large number of drug-resistant strains have been produced, resulting in limited clinical treatment effects, resulting in re...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20C12N1/00A61K35/74C12R1/125A61P1/00A61K35/742
CPCY02A50/30
Inventor 阿尔申巴耶夫·穆罕默德古拉金·瓦列里巴伊古金娜·法尼丽娅扎伊努里·鲁斯特姆张晓静战军孙志强倪冬雁
Owner 烟台绿云生物工程研究院有限公司
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