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Medicine composition for curing inflammatory bone disease and process for preparing the same

A composition and drug technology, applied in the direction of drug combination, bone disease, medical formula, etc., can solve the problems of difficult to stop the disease process, clinical application limitations, and many adverse reactions, so as to inhibit the absorption and destruction of bone tissue, less adverse reactions, Improve the effect of pathological tissue structure

Inactive Publication Date: 2007-12-12
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the various shortcomings of most of the drugs on the market, they generally treat the symptoms but not the root cause, and it is difficult to stop the progress of the disease. There are many adverse reactions after long-term use, and the clinical application is limited.

Method used

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  • Medicine composition for curing inflammatory bone disease and process for preparing the same
  • Medicine composition for curing inflammatory bone disease and process for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 100 grams each of Coptis chinensis, Cortex Phellodendron, and Scutellaria baicalensis; 50 grams each of centipede, scorpion, and gecko.

[0035] 450 grams of raw medicine, the powder is coarse, add water and decoct three times, one hour each time, filter, combine the filtrate, concentrate to nearly 600ml, let cool, filter, add 95% ethanol to the filtrate until the alcohol content of the solution reaches 75%, let it stand Overnight, filter, recover ethanol from the filtrate and concentrate to extract with a relative density of 1.36, add appropriate amount of starch and microcrystalline cellulose, mix evenly, make suitable soft materials and pass through a 22 mesh sieve to make granules, blow dry at 60°C, 20 mesh The granules are sieved, and the granules are filled into the No. 2 capsule shell to finish the product.

Embodiment 2

[0037] 10 grams each of Coptis chinensis, Cortex Phellodendron, and Scutellaria baicalensis, 1 gram each of centipede, Tianlong, and scorpion, crushed into coarse powder, mixed, soaked in 95% ethanol overnight, refluxed three times, combined ethanol solution, filtered, concentrated to 0.75g medicinal materials / ml, added to regular The flavoring agent is obtained as an oral liquid.

Embodiment 3

[0039] 20 grams each of Coptis chinensis, Cortex Phellodendron, and Scutellaria baicalensis, 50 grams each of centipede, Tianlong, and scorpion. The powder is coarse powder, mixed, soaked in 20% ethanol overnight, and refluxed 3 times. Paste, add appropriate amount of starch and microcrystalline cellulose, mix evenly, make suitable soft materials, pass through a 22-mesh sieve to make granules, blow dry at 60°C, granulate with a 20-mesh sieve, and fill the granules into No. 2 capsule shells.

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Abstract

Disclosed is a medicinal composition for curing inflammatory bone disease and process for preparation, which mainly comprises goldthread root, corktree bark, baikal skullcap root, centipede, buthus martensi kirsch, house lizard, inflammation-inhibiting medium IL-1, TNF-alpha, IL-2 and prostaglandin E2.

Description

technical field [0001] The invention belongs to a pharmaceutical composition for treating inflammatory bone disease and a preparation method thereof, in particular to a pharmaceutical composition for treating arthritis, rheumatoid arthritis, ankylosing spondylitis and the like derived from traditional Chinese medicine and an industrially applicable preparation method thereof. Background technique [0002] The inflammatory mediators mainly involved in inflammatory bone disease are IL-1, TNF-α, IL-2, and prostaglandin E2, and are often accompanied by pain. For example, rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial membrane. The disease is characterized by symmetrical joint pain, swelling, and stiffness, accompanied by abnormalities in immune function. Genetics, infection, environment, neuroendocrine, immune system and other complex factors participate in or aggravate the pathological process of rheumatoid arthritis. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61K36/718A61K36/539A61K35/64A61K35/56A61P29/00A61P19/02A61P19/08A61K35/583A61K35/646A61K35/648
Inventor 吴玉林王从品李运曼
Owner CHINA PHARM UNIV
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