Micro-full analytical system chip height positioning method

Abstract

A CMOS chip height location method of micro entire analysis system: uses the standard chip to adjust the height of the light source and the chip working table, the seeable focus point of the light source is smaller or equal to the width of the micro-channel when looking downward; the working chip includes the covering slice and the base slice, the top surface of the base slice bond and the bottom surface of the covering slice joint close by the bonding method, the holes chisels on the covering slice, the micro-channel chisels on the top surface of the base slice, the hole connects with the corresponding micro-channel, the area of the covering slice is bigger than the area of the base slice, forming the working chip sets on the support location surface of the chip working table in order that the support location surface of the covering slice touches with the table-board of the chip working table. The invention can avoid height location error leading by the thickness difference of the chip because of the difference of the material or the processing technology.

Description

technical field [0001] The invention relates to a height positioning method for a miniature total analysis system chip. Background technique [0002] The miniature full analysis system is also called lab-on-a-chip, which integrates laboratory functions including sampling, dilution, reagent addition, reaction, separation, and detection on the chip. Small holes are carved on the surface of the chip, and microchannels are carved in the chip. Small holes are used to store samples, reagents or waste liquid, and different channels are used for sample injection, reagent addition, reaction, separation and detection. In an analytical instrument composed of a chip, the absorption of the light source light by the reagent or sample in the chip, or the degree of excitation by the light source light, etc. are generally measured. Only when the focus point of the light source is exactly on the specific channel of the chip (ie, the microchannel), the light energy in the channel is the stro...

AI Technical Summary

Problems solved by technology

[0005] ② Manual adjustment generally requires a microscope to cooperate, the adjustment is cumbersome and time-consuming, the technical requirements for the adjustment personnel are high, and the work efficiency is low

[0006] ③Automatic adjustment requires a complete system of drivers, detectors, signal discrimination, feedback, and control, which is technically difficult and expensive

Images