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Compound lentinan preparation and its preparing method

The technology of lentinan and compound recipe is applied in the field of compound lentinan preparation and its preparation, which can solve the problems of high import price and the like, and achieve the effects of synergistic treatment, inhibiting the growth of tumor cells and improving the immunity of the body.

Inactive Publication Date: 2008-05-07
上海慈瑞医药科技股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But imports are expensive

Method used

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  • Compound lentinan preparation and its preparing method

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Effect test

Embodiment 1

[0023] Take 2 grams of lentinan for injection, put it into a container and dissolve it with 700 ml of 0.6 mol / L sodium hydroxide aqueous solution at room temperature. After dissolving, add 400 ml of ordinary 20% mannitol injection, stir well, add 0.05 g of sodium cantharidinium, adjust the pH of the solution to 9 with 1 mol / L citric acid solution after dissolving, filter, concentrate to 1000 ml under reduced pressure, sterile filter, Disinfect, measure the content, pack in 1ml / bottle, cool and dry, seal, and get compound lentinan freeze-dried powder for injection.

Embodiment 2

[0025] Take 2 grams of lentinan for injection, put it in a container and dissolve it with 600ml of 0.8mol / L sodium hydroxide aqueous solution at room temperature. After dissolving, add 400ml of ordinary 20% mannitol injection and 1.6 grams of dextran, stir well, and add 0.05 of sodium cantharidinate. After dissolving, adjust the pH of the solution to 9 with 1mol / L citric acid solution, filter, concentrate under reduced pressure to 1000ml, sterile filter, sterilize, measure the content, divide into 1ml / bottle, cool and dry, seal to obtain compound shiitake mushrooms Polysaccharide freeze-dried powder for injection.

Embodiment 3

[0027] Take 2 grams of lentinan for injection, put it into a container and dissolve it with 500 ml of 0.8 mol / L sodium hydroxide aqueous solution at room temperature. After dissolving, add 100 ml of 10% hydroxypropyl-β-cyclodextrin aqueous solution, stir well, add 0.05 g of sodium cantharidate, adjust the pH of the solution to 9 with 1 mol / L citric acid solution after dissolving, filter, add water for injection to 1000 ml , sterile filtration, disinfection, content measurement, sub-packaging, 1ml / bottle, cooling and drying, sealing, to obtain compound lentinan freeze-dried powder injection.

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Abstract

The present invention relates to a compound lentinan preparation and its preparation method. Said method includes the following steps: using sodium hydroxide aqueous solution to dissolve lentinan, adding sodium cantharidinate, using acid solution to regulate pH value, aseptic filtering and preparing compound lentinan water injection according to the operation requirements of Chinese medicine water injection, or adding medicinal auxiliary material, stirring and dissolving them, more adding sodium cantharidinate, using acid solution to regulate pH value, aseptic filtering and preparing compound lentinan freeze-dried powder injection, or adding sodium cantharidinate in dissolving solution, adding hydrochloric acid to regulate pH value, aseptic filtering and preparing compound lentinan infusion solution. Said invention has the effect of inhibiting tumor cell growth and raising immunity of body.

Description

technical field [0001] The invention relates to a compound lentinan preparation and a preparation method thereof. The compound lentinan has the effects of inhibiting the growth of tumor cells and improving the immunity of the body at the same time, and can play a synergistic therapeutic effect in the treatment of cancer, and belongs to the compound pharmaceutical preparation. technical field. Background technique [0002] With the changes in human living environment, living standards and lifestyles and the advancement of medicine, the spectrum of human diseases has undergone significant changes, general infectious diseases have been gradually controlled, and malignant tumors have become increasingly common and seriously threaten human life and quality of life. one of the major diseases. According to the statistics of the World Health Organization, 10 million people suffer from cancer in the world every year, and 7 million people die. It is the second largest killer of human...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K9/08A61K9/14A61K9/19A61P35/00A61K31/34
Inventor 金幸陈林祥朱益峰
Owner 上海慈瑞医药科技股份有限公司
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