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Preparation method of polymer microflow control chip having metal microelectrode

A metal microelectrode and microfluidic chip technology, which is applied to electrochemical variables of materials, material analysis by electromagnetic means, measurement devices, etc., can solve problems such as overplating, weak adhesion between the coating and PC sheets, etc. Achieve the effect of good analytical performance, elimination of non-selective overplating, and easy process control

Inactive Publication Date: 2008-05-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, non-selective overplating is prone to occur when this technology is used to prepare metal microelectrodes on PC chips, and the adhesion between the coating and PC chips is not strong enough.

Method used

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  • Preparation method of polymer microflow control chip having metal microelectrode
  • Preparation method of polymer microflow control chip having metal microelectrode

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] see figure 1 , the steps of preparing an integrated capillary electrophoresis electrochemical detection polycarbonate microfluidic chip with gold microelectrodes are:

[0038] A. Use a low-pressure mercury lamp as a light source and a quartz / chrome plate as a mask to irradiate selected areas on the surface of the 0.5-1mm thick, 4×6cm PC cover sheet 7 for 2.5 hours.

[0039] B. Put the irradiated PC cover slip 7 into 0.36mol / L ethylenediamine-0.5mol / L1-[3'-(N,N-dimethylamino)propyl]-3-ethyl carbon Diimine hydrochloride solution was reacted for 3 hours and washed with distilled water.

[0040] C. Immerse the PC cover sheet 7 reacted in B in a 1mmol / L chloroauric acid solution for 2.5 hours, wash it with water, and then immerse it in a 0.1mol / L sodium borohydride solution for 10 minutes.

[0041] D. Rinse the PC cover sheet 7 reacted in C with water, immerse in 0.2-0.5 mol / L potassium hydrogen sulfide solution, and ultrasonically clean for 30-60 minutes.

[0042] E. Rin...

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Abstract

The invention provides a method for preparing high polymer micro-flow control chip with metallic microelectrode, characterized in integrating photochemical method and chemical plating to generate the microelectrode in the selective region of the high polymer surface; processing a cover plate plated with the microelectrode on the surface and a substrate with cross channel on the surface by oxygen plasma atmosphere and then sealing them by thermal pressing method to obtain the micro-flow control chip. The invention has the advantages of simple preparing technique, low cost and good analyzing effect.

Description

technical field [0001] The invention relates to a method for preparing a capillary electrophoresis electrochemical detection polymer chip with a metal microelectrode. Background technique [0002] Miniaturized Total Analysis Systems (μTAS) is one of the academic frontiers of analytical chemistry, and chip capillary electrophoresis is one of the mainstream research fields in μTAS. At present, chip capillary electrophoresis mostly uses laser-induced fluorescence (LIF) detectors to complete the high-speed, high-efficiency and high-sensitivity separation and analysis of DNA, protein and other important complex biochemical samples. However, most compounds have no natural fluorescence and need to be detected by LIF after fluorescence derivatization, and the LIF detector is bulky, which affects the miniaturization and integration of the entire analysis system. Electrochemical detectors are low in cost, high in sensitivity, easy to integrate, and can directly detect many compounds,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/447G01N27/28
Inventor 陈恒武孔泳
Owner ZHEJIANG UNIV