Preparation method of nonoxinol foamable composition and its quality control method

A technology of nonoxynol and foam agent, which is applied in the field of preparation of contraceptive foam agent, can solve the problems of not being able to penetrate effectively into the deep part of mucosal folds and vaginal fornix, waiting for dissolution time, and large dosage of effervescent suppositories. Reduced irritation, uniform distribution, and wide coating effect
CN100389758CActive Publication Date: 2008-05-28贵州宏宇药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
贵州宏宇药业有限公司
Publication Date
2008-05-28

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Abstract

The invention discloses a preparation method of nonoxinol foamable composition and its quality control method, wherein nonoxinol is used as raw material, and right amount of methyl glycol, polyvidon K3O, stearic acid, wool grease are used as auxiliary material, the quality control method includes an identification method and a content determination method, wherein highly effective liquid item chromatography is employed for color spectrum identification for the main constituents, and absolute ethyl alcohol is used as the dissolvent, as the results, the chromatogram is more clear, the position of the characteristic peak is made more evident, the content of the active ingredients can be controlled better.
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Description

technical field

[0001] The invention relates to a pharmaceutical preparation, in particular to a preparation method and a quality control method of a foam preparation for contraception. Background technique

[0002] Because oral contraceptives often interfere with endocrine effects, causing side effects such as nausea, vomiting, and even irregular vaginal bleeding, the scope of use is limited. However, contraceptives for external use do not interfere with endocrine function and are reversible. Therefore, the research work of external contraceptives has been paid attention to. In 1964, the International Planned Parenthood Federation approved the use of a vaginal spermicide called "nonoxynol ether": the chemical name of nonoxynol ether [Nonoxynol-9] (abbreviated NP-9) is nonylphenol polyoxygen vinyl ether. NP-9 is a good spermicide, which has the advantages of safety, high efficiency and small systemic side effects. It is suitable for contraception in all stages of women o...

Claims

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