Ethoxy chinoline production method

A technology of ethoxyquin and production method, applied in directions such as organic chemistry, can solve the problems of reducing production efficiency, affecting the quality of ethoxyquin, high toxicity and the like, and achieving the effect of improving production efficiency

Inactive Publication Date: 2008-07-16
上海福达精细材料有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The production method of ethoxyquinoline uses p-aminophenethyl ether and acetone as raw materials, and carries out dehydration condensation reaction under the condition of 120°C-240°C in the presence of acid catalyst and solvent, as in the production method introduced in Chinese patent 92100074, After a reaction, p-aminophenethyl ether is not fully converted, so that after the reaction, p-aminophenethyl ether should be separated by rectification and recycled, which reduces production efficiency. Ether content will exceed 1wt%, affects the quality of ethoxyquinoline, because p-aminophenethyl ether is a kind of primary amine, and toxicity is very big, and is a kind of carcinogen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] In a 2 cubic meter reactor, add 1,000 kg of p-aminophenetole, 200 kg of recovered p-aminophenetole, 100 kg of toluene and 125 kg of p-toluenesulfonic acid, start stirring and heat up to 140°C, then start to pass through the rotor The flowmeter drips acetone, and the flow of acetone dripping is divided into four stages:

[0015] The first stage is 70 kg / hour for 6 hours

[0016] The second stage is 50 kg / hour for 6 hours

[0017] The third stage is 30 kg / hour for 10 hours

[0018] The fourth stage is 12 kg / hour for 10 hours

[0019] The whole reaction process takes 32 hours, the reaction temperature is controlled at 140°C to 160°C, the total amount of acetone used is 1140 kg, and the water generated during the reaction is continuously discharged from the water separator. After 24 hours of reaction, replace the water separator The toluene in the tank continued to add dropwise acetone to react for 8 hours. When the reaction reached 32 hours, the reaction solution was ta...

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Abstract

The invention discloses a Method for production of ethyoxyl quinoline, using phenetidine and acetone to be raw matetial, doing dehydration condensation reaction between 140-160 deg C in the condition of acid catalyst and dissolvent exist. In response anaphase, replacing the dissolvent of water separater, transforming the phenetidine completely in one reaction. Using this method can omit the step of rectification; this will improve the production efficiency, make the p-phenetidine of ethyoxyl quinoline less than 1wt% and make the quality of product reach the standard of food additive.

Description

technical field [0001] The invention relates to a production method of an organic compound, in particular to a production method of ethoxyquinoline used as a feed additive. Background technique [0002] As we all know, ethoxyquinoline is widely used as an antioxidant additive in feed in the feed industry, and its chemical name is 6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline . [0003] The production method of ethoxyquinoline uses p-aminophenethyl ether and acetone as raw materials, and carries out dehydration condensation reaction under the condition of 120°C-240°C in the presence of acid catalyst and solvent, as in the production method introduced in Chinese patent 92100074, After a reaction, p-aminophenethyl ether is not fully converted, so that after the reaction, p-aminophenethyl ether should be separated by rectification and recycled, which reduces production efficiency. The ether content will exceed 1wt%, which affects the quality of ethoxyquinoline, because p-amino...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D215/20C07D215/02
Inventor 罗荫培
Owner 上海福达精细材料有限公司
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