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Oral formulation of danshensu and safflower yellow and preparation process thereof

An oral preparation, Danhong technology, used in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of waste of medicinal materials, poor quality stability, impurity, etc., and achieve high bioavailability and less side effects. , the effect of easy selection

Active Publication Date: 2008-10-15
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current ministerial standard adopts the method of extracting salvia miltiorrhiza with alcohol and then co-extracting it with safflower, the purification effect is not good, the content of its active ingredients is not high, and it is not pure, there is a waste of medicinal materials, and the transportation of the injection is inconvenient. Poor quality stability, not conducive to patient use

Method used

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  • Oral formulation of danshensu and safflower yellow and preparation process thereof
  • Oral formulation of danshensu and safflower yellow and preparation process thereof
  • Oral formulation of danshensu and safflower yellow and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This example is the preparation of safflower yellow:

[0047] Wash and dry safflower plus 10 times the weight of 50% ethanol aqueous solution, extract three times in a water bath at 55°C, each extraction time is 30 minutes, combine the three extracts, concentrate the extract at 55°C under reduced pressure, and make The concentrated solution contains 0.5g of crude drug per milliliter, adjust the pH value to 3 with dilute hydrochloric acid, put it on the AB-8 macroporous resin column, let it stand for adsorption for 3 hours, wash the column with 7 times the column volume of distilled water with a pH of 3 to remove sugar, and then Wash the column with 7 times column volume of 30% ethanol aqueous solution for decolorization, discard the first 1 times column volume of 30% ethanol eluate, collect the remaining eluate, concentrate it under reduced pressure, and spray dry the concentrated solution. That is, safflower yellow pigment.

Embodiment 2

[0049] This example is the preparation of safflower yellow:

[0050] Add 8 times the weight of 50% ethanol aqueous solution to the washed and dried safflower, extract twice in a water bath at 60°C, each extraction time is 20 minutes, combine the extracts, concentrate the extracts under reduced pressure at 35°C, and make The concentrated solution contains 0.5g of crude drug per milliliter, adjust the pH value to 3 with dilute hydrochloric acid, put it on the AB-8 macroporous resin column, let it stand for adsorption for 2 hours, wash the column with 8 times the column volume of distilled water with a pH of 3 to remove sugar, and then Wash the column with 8 times column volume of 30% ethanol aqueous solution for decolorization, discard the first 30% ethanol eluate of 1 column volume, collect the remaining eluate, concentrate it under reduced pressure, and spray dry the concentrated solution. That is, safflower yellow pigment.

Embodiment 3

[0052] This example is the preparation of safflower yellow:

[0053]Add 12 times the weight of washed and dried safflower to 50% ethanol aqueous solution, extract four times in a water bath at 50°C, each extraction time is 40 minutes, combine the four extracts, and concentrate the extract at 45°C under reduced pressure , so that the concentrated solution contains 0.5g of crude drug per milliliter, adjust the pH value to 3 with dilute hydrochloric acid, put it on the AB-8 macroporous resin column, let it stand for adsorption for 2.5 hours, wash the column with 6 times the column volume of distilled water with a pH of 3 to remove sugar , then wash the column with 6 times column volume of 30% ethanol aqueous solution for decolorization, discard the first 30% ethanol eluate of 1 column volume, collect the remaining eluate, concentrate it under reduced pressure, and spray the concentrate Dry to obtain safflower yellow.

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Abstract

The invention relates to a danhong oral agent and relative production, wherein said agent comprises Danshen element and carthamus tinctorius yellow colour, while the content of Danshen is 2-4 times of carthamus tinctorius yellow colour; and said agent can be tablet, capsule, drop, etc. And the production comprises that: preparing carthamus tinctorius yellow colour and preparing final agent. Said method can obtain high purity drug, high utilization, and low side effect, to treat coronary disease, angina pectoris, etc.

Description

technical field [0001] The invention relates to a Danhong oral preparation and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza, according to the existing literature: Salvia miltiorrhiza was first recorded in "Shen Nong's Materia Medica", and many herbal medicines have been recorded in successive dynasties. Indications are: "dispelling blood stasis and relieving pain, promoting blood circulation and promoting menstruation, clearing heart and eliminating troubles. It is used for irregular menstruation, amenorrhea dysmenorrhea, accumulation of lumps, tingling pain in chest and abdomen, sore swelling and pain, upset and insomnia; hepatosplenomegaly, angina pectoris" . It shows that Salvia miltiorrhiza has various effects in clinical application. [0003] The chemical composition of Danshen can be divided into water-soluble comp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K36/537A61K9/00A61K9/16A61K9/20A61K9/48A61P9/10A61K31/192
Inventor 郭爱华
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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