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Compound preparation of notoginseng and safflower for treating cardiovascular and cerebrovascular diseases
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A technology for cardiovascular and cerebrovascular diseases, Panax notoginseng, applied in the field of medicine, can solve the problems of difficult quality control, unknown mechanism, unstable efficacy and so on
Active Publication Date: 2009-01-14
GUANGZHOU YIPINHONG PHARMA +4
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Abstract
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Problems solved by technology
However, the traditional Chinese medicine compound has the disadvantages of unclear ingredients, unknown mechanism, difficult quality control, and unstable curative effect.
Method used
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Embodiment 1
[0046] Precisely weigh 2g of safflower yellow and 2g of Panax notoginseng saponins, mix them with an appropriate amount of water for injection and dissolve them, then add 4g of mannitol, pass through a 0.15μm microporous membrane after dissolving, divide the filtrate and freeze-dry to obtain injection freeze-dried powder.
Embodiment 2
[0048] Accurately weigh 1g of safflower yellow, add appropriate amount of water for injection to dissolve; accurately weigh 7g of Panax notoginseng total saponins, add appropriate amount of water for injection to dissolve. Combine the two parts of the solution, prepare a 1000ml liquid medicine according to a conventional method, filter, fine filter, pot, sterilize, and test to obtain a total of 50 injections of 20ml / bottle.
Embodiment 3
[0050] Take 1 kg of safflower medicinal material, pulverize, dry, and pass through a 100-mesh sieve; take 0.1 kg of notoginseng medicinal material, pulverize, dry, and pass through a 60-mesh sieve. Mix the powders of the two medicinal materials evenly, put them into capsule shells, and make 5000 capsules.
[0051]
[0052]
[0053] Table 3 Myocardial infarction range after coronary artery ligation in dogs (x±SD, n=5)
[0054]
[0055] The impact of table 4 on the neurology score of rat cerebral ischemia 2h reperfusion 24h (x ± SD)
[0056]
[0057] Compared with the model control group * P** P<0.01,
[0058] The impact of table 5 on the cerebral infarction volume of rat cerebral ischemia reperfusion (%, x ± SD)
[0059]
[0060] Compared with the model control group, * P** P<0.01,
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Abstract
A Chinese medicine for treating cerebral infarction, cerebral ischema, coronary heart disease, angina pectoris, myocardiac ischema, myocardiac infarction, heart failure and arrhythmia is prepared from notoginseng and safflower.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases, specifically the effective parts or extracts obtained from Chinese medicine Sanqi and safflower, or extracted from Sanqi and safflower. A composition made of active ingredients in a certain proportion. Background technique [0002] Safflower promotes blood circulation and stimulates menstruation, removes blood stasis and relieves pain, and is used for various blood circulation disorders. It is clinically used as a decoction, and its main water-soluble component is safflower yellow. [0003] Panax notoginseng is a traditional traditional Chinese medicine for dispelling blood stasis, stopping bleeding, reducing swelling and relieving pain. A large number of studies have shown that the active ingredient of Panax notoginseng is total saponins of Panax notoginseng. The con...
Claims
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Application Information
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