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Use of desiccant in active bacteria drying

A technology of live bacteria preparation and desiccant, which is applied in the field of desiccant and its preparation, can solve the problem of being easily affected by temperature, oxygen, pressure and moisture in the external environment, affecting the survival environment of the active ingredient Bifidobacterium adolescentis, Affected by external temperature, oxygen and other problems, it achieves the effect of high practical application value, easy industrial application, and not affected by environmental humidity

Active Publication Date: 2009-05-27
LIVZON PHARM GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The characteristics of this product determine the requirements for packaging materials: Bifidobacterium juvenileum (DM8504) is a Gram-positive anaerobic bacterium that is easily affected by external temperature and oxygen. Drugs and food are extremely susceptible to the influence of temperature, oxygen, pressure and moisture in the external environment, especially the oxygen and moisture in the air can easily cause chemical reactions such as oxidation and hydrolysis of the product, which will promote the deterioration of bacterial proteins and lead to live The number of bacteria drops sharply, and the existence of oxygen and moisture will also promote the reproduction of other microorganisms, so it is required to isolate air and moisture, and it is best to create a closed and dry environment isolated from the outside world; in addition, because the excipient lactose is easy to absorb moisture, Moisture will make lactose absorb moisture and become sticky, forming clumps or lumps, which will affect the living environment of the active ingredient Bifidobacterium adolescentis, so this product needs a moisture-proof packaging
At present, the desiccant used in the packaging of Changle is a product of Senna (Kunshan) Company in Germany. This product is expensive, which greatly increases the production cost of Changle, thus increasing the economic burden of patients
So far, there have been no reports on desiccants used in live bacterial preparations in China

Method used

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  • Use of desiccant in active bacteria drying
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  • Use of desiccant in active bacteria drying

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, the preparation of desiccant and its effect detection

[0023] 1. Preparation of desiccant for active fungal preparations

[0024] Molecular sieves of model 0401267 (aperture 3A, diameter 0.5-1.25 mm) purchased from Nanjing Heyi Chemical Co., Ltd. and silica gel (diameter 1.5 mm) of model 0466906 purchased from Nanjing Heyi Chemical Co., Ltd. were pressed The ratio of parts by weight is 3:2 and mixed to obtain a desiccant.

[0025] 2. Detection of drying effect of live fungal preparations

[0026] Taking Changle produced by Livzon Pharmaceutical Factory as an example, the drying effect of the desiccant on the active bacterial agent in step 1 was tested. Pack (2.5g desiccant / 20 capsules) with the plastic bottle packing (2.5g desiccant / 20 capsules) that desiccant of the present invention is housed and the blister eye aluminum foil packing that does not have desiccant of the present invention, preserve at 25 ℃, and at 0, 3, 6, 9, 12.18 months, detect the n...

Embodiment 2

[0034] Embodiment 2, the preparation of desiccant and its effect detection

[0035] 1. Preparation of desiccant

[0036] The model purchased from Shenzhen Chunwang Industrial Co., Ltd. is 051470 molecular sieve (aperture is 1A) and the model purchased from Shenzhen Chunwang Industrial Co., Ltd. is 056870 silica gel (diameter is 0.5mm) in parts by weight Mix 5:8 to get desiccant.

[0037] 2. Drying effect detection

[0038] Use the same method as in Example 1 to detect the drying effect of the desiccant prepared in step 1 on the Enterobacteriaceae agent produced in the same batch (20030404). The test results are shown in Table 4. Under the packaging conditions of the desiccant of the present invention, the bacteria agent is still qualified after 18 months of preservation, but under the ordinary packaging conditions without desiccant, the number of viable bacteria in the bacteria agent is unqualified after 6 months of preservation, indicating that the drying agent of the prese...

Embodiment 3

[0041] Embodiment 3, the preparation of desiccant and its hygroscopicity detection

[0042] 1. Preparation of desiccant

[0043] The molecular sieve (aperture is 6A) of model 058740 purchased from Hangzhou Hailiang Desiccant Co., Ltd. and the silica gel (diameter of 3.5mm) purchased from Hangzhou Hailiang Desiccant Co., Ltd. of model 059412 are compared in parts by weight Mix 1:1 to get desiccant.

[0044] 2. Hygroscopicity detection

[0045]Now test the hygroscopicity of the desiccant prepared in step 1. The specific method is: take the RTOP artificial climate box produced by Suzhou Shandao Environmental Test Equipment Co., Ltd., set the initial humidity in the box to 100% RH, and then close all Environmental factor adjustment equipment, under the condition that the desiccant (50g) prepared in step 1 and no desiccant are installed in the box respectively, the humidity changes in the box at different times are detected, and the test results are shown in Table 5. Under the c...

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Abstract

The invention relates to a drying agent used in viable bacteria agent, and relative production, wherein it is formed by molecule screen and silica gel at 1-5:1-8 ration. It is prepared by mixing silica gel and molecule screen, with better adsorption and wide application.

Description

technical field [0001] The invention relates to a desiccant and a preparation method thereof, in particular to a desiccant applicable to live bacteria preparations and a preparation method thereof. Background technique [0002] A desiccant is a dehydrating agent that absorbs moisture from the atmosphere. Its drying principle is to physically absorb water molecules in its own structure or chemically absorb water molecules and change its chemical structure to become another substance. At present, there are various desiccant products on the market, among which silica gel desiccant and molecular sieve desiccant are two main products: [0003] Silica gel desiccant: The main component is silica, which is purified and processed from natural minerals into granular or beaded form. As a desiccant, its microporous structure (average 2A) has a good affinity for water molecules. The most suitable hygroscopic environment for silica gel desiccant is room temperature (20-32°C) and high h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D53/28B01J20/18
Inventor 胡振湘徐乐意苏日佳吴起娟闫松杨毅
Owner LIVZON PHARM GRP INC
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