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Self emulsifying soft capsule of breviscapine and its preparation
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A technology of self-emulsifying soft capsules and breviscapine, which is applied in the field of medicine, can solve the problems of no breviscapine, etc., and achieve the effects of improving water solubility and bioavailability, rapid onset of action, and helpful storage and preservation
Active Publication Date: 2009-07-22
SHENZHEN NEPTUNUS PHARM CO LTD
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Abstract
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Problems solved by technology
[0006] There is no public report on breviscapine self-emulsification technology
Method used
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Embodiment 1
[0041] The composition of the prescription is as follows: (g)
[0042] Breviscapine 40
[0043] Propylene glycol 160
[0044] Ethyl oleate 35
[0045] Polyoxyethylene (20) sorbitan oleate 160
[0046] Made 1000 softgels in total
[0047] Preparation process: Weigh breviscapine according to the above prescription amount, then add propylene glycol, dissolve it by ultrasonic at 40°C, add oil phase and emulsifier and other excipients according to the prescription, stir well and make soft capsules.
Embodiment 2
[0049] The composition of the prescription is as follows: (g)
[0050] Breviscapine 40
[0051]Acrylic Carbonate 80
[0052] Sorbitan Oleate 120
[0053] Macroglycerides Almond Oleate 240
[0054] Made 1000 softgels in total
[0055] Preparation process: Weigh breviscapine according to the above prescription amount, then add propylene carbonate, dissolve it by ultrasonic at 40°C, add oil phase and emulsifier and other excipients according to the prescription, stir well and make soft capsules.
Embodiment 3
[0057] The composition of the prescription is as follows: (g)
[0058] Breviscapine 40
[0059] Glyceraldehyde 40
[0060] Coconut Oil C8 / C10 Mono- or Di-Glycerides 20
[0061] Liquid Lecithin 400
[0062] Made 1000 softgels in total
[0063] Preparation process: Weigh breviscapine according to the above prescription amount, then add glycerol furfural, dissolve it by ultrasonic at 40°C, add oil phase and emulsifier and other excipients according to the prescription, stir well and make soft capsules.
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Abstract
The invention relates to breviscapine self-emulsifying soft capsules and a preparation method thereof, which can effectively improve the bioavailability of breviscapine and improve the curative effect of drugs. The breviscapine self-emulsifying soft capsule comprises breviscapine, a co-emulsifier, an emulsifier and an oil phase, and its composition ratio is: 1:1-10:0.5-10:0.5-10. Preparation method: Weigh an appropriate amount of breviscapine, add the prescribed amount of co-emulsifier, dissolve it ultrasonically at 40°C, add oil phase, emulsifier and other auxiliary materials according to the prescribed amount, stir evenly, and press into soft capsules.
Description
Technical field: [0001] The invention relates to the technical field of medicine, in particular to a scutellarin self-emulsifying soft capsule and a preparation method thereof. Background technique: [0002] Breviscapine is an active ingredient of flavonoids separated and extracted from the plant Erigeron breviscapine. It mainly contains scutellarin, a small amount of breviscapine and other flavonoids. It can expand cerebral blood vessels, reduce cerebral vascular resistance, increase cerebral blood flow, improve Microcirculation, and anti-platelet aggregation. Breviscapine is clinically used to treat cerebral thrombosis, cerebral infarction, cardiovascular disease, acute viral myocarditis in children, hyperviscosity, vertigo, thrombophlebitis, retinal vein occlusion, chronic asthmatic bronchitis, Acute initial renal failure, adjuvant treatment of diabetes, etc. [0003] Since the 1970s, many domestic units have used breviscapine tablets as raw materials to make various pr...
Claims
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Application Information
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