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Compound recipe copper sulfate cold cream

A copper sulfate and cold cream technology, applied in the field of medicine, can solve problems such as poor curative effect and patient pain, and achieve the effects of fast onset, avoiding side effects and good curative effect.

Inactive Publication Date: 2009-09-02
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

External application of psoralen is not effective if it is not irradiated with ultraviolet rays, but it is easy to cause blisters when exposed to ultraviolet rays, causing pain to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 prepares compound copper sulfate cold cream

[0013] Components and ratio:

[0014] 120g copper sulfate

[0015] Urea 1200g

[0016] Clopetasol Propionate 6g

[0017] Azone 240ml

[0018] Stearic acid 720g

[0019] Stearyl Alcohol 720g

[0020] 1080ml liquid paraffin

[0021] 720g white petrolatum

[0022] Glycerin 1200g

[0023] Sorbic acid 6 grams

[0024] Tween-80 528ml

[0025] Span-80 192ml

[0026] DMSO 5ml

[0027] Purified water 6000ml

[0028] Preparation:

[0029] (1) Prepare the oil phase: put stearic acid, stearyl alcohol, liquid paraffin, white vaseline, and glycerin in an evaporating dish according to the proportion, heat it on a water bath to 75°C and melt it, keep it warm for later use, and then add clopetasol propionate Dissolve it with dimethyl sulfoxide and add it to form an oily phase.

[0030] (2) Preparation of the water phase: add copper sulfate, urea, azone, sorbic acid, Tween-80, and Span-80 into distilled water accor...

Embodiment 2

[0032] Embodiment 2 prepares compound copper sulfate cold cream

[0033] Components and ratio:

[0034] Copper Sulfate 100g

[0035] Urea 1000g

[0036] Clopetasol Propionate 3g

[0037] Azone 250ml

[0038] Stearic acid 1000g

[0039] 1800ml liquid paraffin

[0040] 720g white petrolatum

[0041] Sorbic acid 6 grams

[0042] Tween-80 528ml

[0043] Span-80 192ml

[0044] DMSO 3ml

[0045] Purified water 6000ml

[0046] The preparation method is the same as in Example 1.

Embodiment 3

[0047] Embodiment 3 prepares compound copper sulfate cold cream

[0048] Components and ratio:

[0049] copper sulfate 150g

[0050] Urea 1500g

[0051] Clopetasol Propionate 10g

[0052] Azone 200ml

[0053] Stearyl Alcohol 1000g

[0054] 1000g white petrolatum

[0055] Glycerin 1500g

[0056] Sorbic acid 6 grams

[0057] Tween-80 528ml

[0058] Span-80 200ml

[0059] Dimethyl sulfoxide 10ml

[0060] Purified water 6000ml

[0061] The preparation method is the same as in Example 1.

[0062] Clinical trials:

[0063] 32 patients clinically diagnosed as localized stable vitiligo patients were randomly divided into 3 groups, respectively treated with compound copper sulfate cold cream, 1% clopetasol propionate ointment, and 2% copper sulfate solution for external use, and conducted a controlled study to observe Efficacy and adverse reactions. Medication 2 times a day, shared medicine for 2 months. Efficacy standard: recovery: all white spots subsided, and normal s...

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PUM

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Abstract

The invention discloses a compound cupric sulfate cold cream to treat leukoderma in the medical technological domain, which is composed of cupric sulfate, glucocorticoids clobetasol propionate, transdermal accelerant and cold cream base. Because cupric sulfate and glucocorticoids clobetasol propionate are prepared into composite preparation, better treatment effect, quicker function and lower toxic action can be achieved when the local concentration is much lower than that of the single preparation of cupric sulfate and glucocorticoids clobetasol propionate.

Description

technical field [0001] The invention relates to the technical field of medicines, and relates to an external preparation compound copper sulfate cold cream for treating vitiligo. Background technique [0002] Vitiligo is a common skin disease with an incidence rate of about 2%. It is easy to diagnose but difficult to treat. Early studies have confirmed that the cause of vitiligo is related to the lack of trace element copper in the body and the body's autoimmunity to melanocytes, but oral administration of copper preparations can easily cause poisoning. At present, the commonly used treatment methods mainly include photochemotherapy, narrow-wave ultraviolet irradiation, autologous epidermal grafting, external application of glucocorticoid ointment or psoralen solution, etc. Prolonged application of photochemotherapy can easily damage the lens of the patient's eye, which may lead to cataracts. Narrow-wave ultraviolet radiation requires complex equipment, high treatment cost...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/34A61K9/00A61K47/18A61K47/22A61K47/44A61P17/00A61K31/57
Inventor 吴建华顾军温海刘继勇
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY