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Chinese medicinal soft capsule effective ingredient detection method

A technology of active ingredients and detection methods, applied in the drug composition of traditional Chinese medicine soft capsules, and in the field of drug composition of Jinshuibao soft capsules, can solve problems such as undiscovered and labor-intensive

Inactive Publication Date: 2010-01-20
RENHE GRP DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex characteristics of traditional Chinese medicine prescriptions, there is no unified standard for the preparation method of traditional Chinese medicine soft capsules. To achieve this goal, labor must be paid

Method used

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  • Chinese medicinal soft capsule effective ingredient detection method
  • Chinese medicinal soft capsule effective ingredient detection method
  • Chinese medicinal soft capsule effective ingredient detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prescription: fermented Cordyceps powder 1.8kg, polyethylene glycol-400 2.4kg, propylene glycol 0.35kg

[0037] Preparation method: Take the fermented Cordyceps fungus powder, add propylene glycol and polyethylene glycol-400, pass through a colloid mill to grind for 20 minutes, and press it into soft capsules on a soft capsule machine.

Embodiment 2

[0039] Prescription: fermented Cordyceps powder 2.2kg, polyethylene glycol-400 2.8kg, propylene glycol 0.45kg, ethylparaben 0.1kg

[0040] Preparation method: Take the fermented Cordyceps fungus powder, add propylene glycol, polyethylene glycol-400 and ethylparaben, pass through a colloid mill to grind for 20 minutes, and press into soft capsules on a soft capsule machine.

Embodiment 3

[0042] Prescription: fermented Cordyceps powder 2kg, polyethylene glycol-400 2.6kg, propylene glycol 0.4kg

[0043] Preparation method: take fermented Cordyceps fungus powder, add propylene glycol and polyethylene glycol-400, mix well, and make 10,000 soft capsules

[0044] Quality Standard:

[0045]Identification (1) Take adenine reference substance and adenosine reference substance, add dilute ethanol to make a solution containing 10ug per 1ml, respectively, as the reference substance solution. Test according to high performance liquid chromatography (Chinese Pharmacopoeia, an appendix VID of the 2000 edition), using octadecylsilane bonded silica gel as a filler, and using 0.5% tetrahydrofuran in a phosphate buffer solution [0.066mol / L potassium dihydrogen phosphate solution- 0.066mol / L disodium hydrogen phosphate solution (4: 6)] is mobile phase, and detection wavelength is 260nm, absorbs each 20ul of need testing solution and above-mentioned reference substance solution u...

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Abstract

The present invention discloses Jinshuibao soft capsule prepared with fermented aweto powder as main medicine component and containing diluent and softening agent. The soft capsule has relatively high stability. In addition, the preparation process and its quality control method is also disclosed.

Description

technical field [0001] The invention discloses a drug composition of a traditional Chinese medicine soft capsule, in particular discloses a drug composition of a Jinshuibao soft capsule, which belongs to the field of traditional Chinese medicine. At the same time, the invention also discloses a preparation method and an effective component detection method of the soft capsule. Background technique [0002] Fermented Cordyceps powder is a dry powder of the mycelium obtained by liquid fermentation of the asexual generation of the ergotaceae fungus Cordyceps sinensis isolated from fresh Cordyceps sinensis in Qinghai. , can be used for the adjuvant treatment of cough, asthma, hemoptysis, back pain and other diseases caused by deficiency of lung and kidney, and chronic bronchitis. Clinically, it has been made into various dosage forms, including tablets, capsules, and oral liquids, such as Jinshuibao Tablets. These drugs have played a greater role in the treatment of lung and k...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/00A61K36/068A61K9/48A61P1/14A61P11/00
Inventor 杨文龙
Owner RENHE GRP DEV CO LTD