Microemulsion of hypocrellin, and its preparing method

A technology of rhodopsin and rhodopsin A is applied in the directions of emulsion delivery, pharmaceutical formulations, and medical preparations containing active ingredients, which can solve the lack of biocompatibility and stability of target cell-selective amphiphilic materials. It can solve the problems of poor performance and easy deterioration, so as to achieve the effect of good targeting and biodegradability, high stability and easy operation.

Inactive Publication Date: 2007-07-25
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also many problems, such as the micellar system can have high stability, but there are problems such as lack of selectivity to target cells and biocompatibility of amphiphile materials; liposomes have high targeting and drug release properties, but the semi-fluid liposome preparations have poor stability, rapid leakage and perishability

Method used

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  • Microemulsion of hypocrellin, and its preparing method
  • Microemulsion of hypocrellin, and its preparing method
  • Microemulsion of hypocrellin, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Add 2mg Hypocretin B (HB) to 200mg egg yolk lecithin, 200mg soybean oil, and 100mg Tween-80 in a pear-shaped bottle, stir in a water bath at 40°C to mix evenly, keep stirring, and slowly add 0.27M glycerol aqueous solution 3.41 mL, continue to stir for half an hour to obtain colostrum, and place the gained colostrum in an ice-water bath with a probe-type ultrasonic instrument at 80w for 1 hour to obtain 4 mL of hypocrellin microemulsion, and use a microporous film as a sterile filter (pore size Use 0.22μm) to sterilize and pack with nitrogen and store in the refrigerator at 4°C.

Embodiment 2

[0029] Add 200 mg soybean lecithin, 200 mg olive oil, and 100 mg Tween-60 to 2 mg hypocretin A (HA) in a pear-shaped bottle, stir in a water bath at 40°C to mix evenly, keep stirring, and slowly add 0.27M glycerin aqueous solution 3.41 mL, continue to stir for half an hour to obtain colostrum, place the gained colostrum in an ice-water bath, and use a probe-type ultrasonic instrument at 80w for 1 hour to obtain 4 mL of hypocrellin microemulsion, and use a microporous film as a sterilizing filter ( The pore size is 0.22 μm) and sterilized, packed with nitrogen and placed in a refrigerator at 4°C.

Embodiment 3

[0031] Put 2.8mg Hypocretin B (HB), 200mg egg yolk lecithin, 200mg seabuckthorn oil, and 100mg poloxamer 188 in a pear-shaped bottle, add 1mL chloroform to dissolve to obtain a red solution, and rotatively evaporate in a water bath at 50°C for half an hour to form a thin Layer, dry with argon, slowly add 3.41mL of 0.2M diglycerin aqueous solution under stirring, continue to stir for half an hour to obtain colostrum, place the obtained colostrum in an ice-water bath, and use a probe-type ultrasonic instrument at 80w for 1 hour to obtain bamboo red Bacteroidin microemulsion 4mL, sterilized with a microporous membrane as a sterile filter (aperture 0.22 μm), filled with nitrogen, sealed and stored in a refrigerator at 4°C.

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Abstract

A microemulsion of hypocrelline for venous injection with high stability, target nature and biodegradability and strong photodynamic function is proportionally prepared from hypocrelline, natural oil, surfactant, water-soluble polyol, and water. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a hypocretin microemulsion and a preparation method thereof. Background technique [0002] Hypocrellin is a kind of natural phytochrome extracted from Hypocrellabambusae (B.et Br.) Sacc., a parasitic fungus native to Arrow bamboo in Yunnan, my country. It has singlet oxygen quantum yield High, clear structure, good chemical modification, low dark toxicity, fast metabolism in vivo and other ideal photosensitizer characteristics, it is recognized as one of the most promising new photodynamic photosensitizers. Folks have used hypocreamin to treat stomach pain, arthritis, and skin diseases; it has been proven that it has potential uses in photodynamic anti-HIV, anti-tumor, and microvascular diseases. Hypocretins include hypocrellin A (HA, formula I structure, molecular formula C 30 h 26 o 16 ) and hypocrellin (HB, formula II structure, molecular formula C 30 h 24 o 3 ). [0003] [0004] (Formula I) (Formula II) [0005]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K9/107A61P1/04A61P29/00A61P19/02A61P35/00
Inventor 赵井泉刘昕顾瑛刘丽红
Owner INST OF CHEM CHINESE ACAD OF SCI
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